LKT/SWAINSONINE/S881011/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/SWAINSONINE/S881011/5 mg

LKT/SWAINSONINE/S881011/5 mg

商品编号： S881011-5mg

品牌： lktlabs

市场价： ¥10580.00

美元价： 6348.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID S881011

Cas No. 72741-87-8

Purity ≥98%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Swainsonine is an indolizidine alkaloid isolated from the fungus metharhizium anisopliae. It is an antineoplastic immunomodulator. Swainsonine restores the capacities of immunodeficient mice such that the growth and metastasis of implanted tumors are inhibited. The anti-metastatic effect may be the result of the stimulation of lymphocyte proliferation and augmentation of natural killer cell reactivity of the immune system. Swainsonine has been found to induce apoptosis in esophageal squamous cell carcinoma and human lung cancer cells as well as C6 glioma cells. In addition to its anti-proliferative effect on tumor cells, swainsonine has been found to potentiate cytotoxic effects of chemotherapeutic drugs such as paclitaxel and cisplatin.

Product Info

Cas No.	72741-87-8
Purity	≥98%
Formula	C₈H₁₅NO₃
Formula Wt.	173.20
Chemical Name	(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol
IUPAC Name	(1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Synonym	SwainMoia; (1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol; D-Swainsonine; 8A,B-INDOLIZIDINE-1,2A,8B-TRIOL;SWAINSONINE;Tridolgosir; SwainMoia; (1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol;
Solubility	10 mg/ml in water, 5 mg/ml in methanol
Appearance	Beige lyophilized powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

Info Sheet	S881011 Info Sheet PDF

References

Mohla S, Humphries MJ, White SL, et al. Swainsonine: a new antineoplastic immunomodulator. J Natl Med Assoc. 1989, 81(10):1049-56. PMID: 2509720 PMCID: PMC2571577.

Kino T, Inamura N, Nakahara K, et al. Studies of an immunomodulator, swainsonine. II. Effect of swainsonine
on mouse immunodeficient system and experimental murine tumor. J Antibiot (Tokyo). 1985, 38(7):936-40. PMID: 3928564.

Dennis JW. Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasis. Cancer Res. 1986, ;46(10):5131-6. PMID: 3093060.

White SL , Schweitzer K, Humphries MJ, Olden K. Stimulation of DNA synthesis in murine lymphocytes by the drug swainsonine: immunomodulatory properties. Biochem Biophys Res Commun. 1988, 150(2):615-25. PMID: 3124836.

Humphries MJ , Matsumoto K, White SL, et. al. Augmentation of murine natural killer cell activity by swainsonine, a new antimetastatic immunomodulator. Cancer Res. 198, 48(6):1410-5. PMID: 3125963

Li Z , Huang Y, Dong F, et al. Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway. J Biosci. 2012, 37(6):1005-16. PMID: 23151791

Li Z , Xu X, Huang Y, et al. Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts. Int J Biol Sci. 2012, 8(3):394-405. doi: 10.7150/ijbs.3882. Epub 2012 Feb 24. PMID: 22393311 PMCID: PMC3291856 DOI: 10.7150/ijbs.3882

Sun JY , Yang H, Miao S, et al. Suppressive effects of swainsonine on C6 glioma cell in vitro and in vivo. Phytomedicine. 2009, 16(11):1070-4. doi: 10.1016/j.phymed.2009.02.012. Epub 2009 May 8. PMID: 19427771 DOI: 10.1016/j.phymed.2009.02.012.

You N , Liu W, Wang T, et al. Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo. Oncol Rep. 2012, 28(6):2091-100. doi: 10.3892/or.2012.2035. Epub 2012 Sep 17. PMID: 22993037 DOI: 10.3892/or.2012.2035

Santos FM , Latorre AO, Hueza IM, et al. Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo. Phytomedicine. 2011, 18(12):1096-101. doi: 10.1016/j.phymed.2011.06.005. Epub 2011 Jul 16. PMID: 21763115 DOI: 10.1016/j.phymed.2011.06.005.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂