LKT/SWAINSONINE/S881011/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/SWAINSONINE/S881011/10 mg

LKT/SWAINSONINE/S881011/10 mg

商品编号： S881011-10mg

品牌： lktlabs

市场价： ¥19060.00

美元价： 11436.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDS881011

CasNo.72741-87-8

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Swainsonineisanindolizidinealkaloidisolatedfromthefungusmetharhiziumanisopliae.Itisanantineoplasticimmunomodulator.Swainsoninerestoresthecapacitiesofimmunodeficientmicesuchthatthegrowthandmetastasisofimplantedtumorsareinhibited.Theanti-metastaticeffectmaybetheresultofthestimulationoflymphocyteproliferationandaugmentationofnaturalkillercellreactivityoftheimmunesystem.SwainsoninehasbeenfoundtoinduceapoptosisinesophagealsquamouscellcarcinomaandhumanlungcancercellsaswellasC6gliomacells.Inadditiontoitsanti-proliferativeeffectontumorcells,swainsoninehasbeenfoundtopotentiatecytotoxiceffectsofchemotherapeuticdrugssuchaspaclitaxelandcisplatin.

ProductInfo

CasNo.	72741-87-8
Purity	≥98%
Formula	C₈H₁₅NO₃
FormulaWt.	173.20
ChemicalName	(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol
IUPACName	(1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Synonym	SwainMoia; (1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol; D-Swainsonine; 8A,B-INDOLIZIDINE-1,2A,8B-TRIOL;SWAINSONINE;Tridolgosir;SwainMoia; (1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol;
Solubility	10mg/mlinwater,5mg/mlinmethanol
Appearance	Beigelyophilizedpowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	S881011InfoSheetPDF

References

MohlaS,HumphriesMJ,WhiteSL,etal.Swainsonine:anewantineoplasticimmunomodulator.JNatlMedAssoc.1989,81(10):1049-56.PMID:2509720PMCID:PMC2571577.

KinoT,InamuraN,NakaharaK,etal.Studiesofanimmunomodulator,swainsonine.II.Effectofswainsonine
onmouseimmunodeficientsystemandexperimentalmurinetumor.JAntibiot(Tokyo).1985,38(7):936-40.PMID:3928564.

DennisJW.Effectsofswainsonineandpolyinosinic:polycytidylicacidonmurinetumorcellgrowthandmetastasis.CancerRes.1986,;46(10):5131-6.PMID:3093060.

WhiteSL,SchweitzerK,HumphriesMJ,OldenK.StimulationofDNAsynthesisinmurinelymphocytesbythedrugswainsonine:immunomodulatoryproperties.BiochemBiophysResCommun.1988,150(2):615-25.PMID:3124836.

HumphriesMJ,MatsumotoK,WhiteSL,et.al.Augmentationofmurinenaturalkillercellactivitybyswainsonine,anewantimetastaticimmunomodulator.CancerRes.198,48(6):1410-5.PMID:3125963

LiZ,HuangY,DongF,etal.Swainsoninepromotesapoptosisinhumanoesophagealsquamouscellcarcinomacellsinvitroandinvivothroughactivationofmitochondrialpathway.JBiosci.2012,37(6):1005-16.PMID:23151791

LiZ,XuX,HuangY,etal.Swainsonineactivatesmitochondria-mediatedapoptoticpathwayinhumanlungcancerA549cellsandretardsthegrowthoflungcancerxenografts.IntJBiolSci.2012,8(3):394-405.doi:10.7150/ijbs.3882.Epub2012Feb24.PMID:22393311PMCID:PMC3291856DOI:10.7150/ijbs.3882

SunJY,YangH,MiaoS,etal.SuppressiveeffectsofswainsonineonC6gliomacellinvitroandinvivo.Phytomedicine.2009,16(11):1070-4.doi:10.1016/j.phymed.2009.02.012.Epub2009May8.PMID:19427771DOI:10.1016/j.phymed.2009.02.012.

YouN,LiuW,WangT,etal.Swainsonineinhibitsgrowthandpotentiatesthecytotoxiceffectofpaclitaxelinhepatocellularcarcinomainvitroandinvivo.OncolRep.2012,28(6):2091-100.doi:10.3892/or.2012.2035.Epub2012Sep17.PMID:22993037DOI:10.3892/or.2012.2035

SantosFM,LatorreAO,HuezaIM,etal.IncreasedantitumorefficacybythecombinedadmiNISTrationofswainsonineandcisplatininvivo.Phytomedicine.2011,18(12):1096-101.doi:10.1016/j.phymed.2011.06.005.Epub2011Jul16.PMID:21763115DOI:10.1016/j.phymed.2011.06.005.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂