LKT/TAMOXIFEN CITRATE/T0250/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/TAMOXIFEN CITRATE/T0250/1 g

LKT/TAMOXIFEN CITRATE/T0250/1 g

商品编号： T0250-1g

品牌： lktlabs

市场价： ¥2080.00

美元价： 1248.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDT0250

CasNo.54965-24-1

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Tamoxifenisaselectiveestrogenreceptormodulator(SERM)thatactsasanERagoNISTintheendometriumandasanERantagonistinbreasttissue;italsoinhibitsPKC.Tamoxifenexhibitsanticancerchemotherapeutic,anti-angiogenic,anti-osteoporotic,andantipsychoticactivities.Tamoxifenisalsoaprodrug,transformedintotheactivemetabolite4-hydroxytamoxifeninvivo.TamoxifenshowssomebenefitinclinicalsettingsinthetreatmentofbipolarIdisorderandothermooddisorders.Inanimalmodels,tamoxifendecreasesbloodvesselformationandinhibitsangiogenesis.Inosteoclasts,thiscompoundinducesapoptosisbyincreasingexpressionofFasL.Additionally,tamoxifenactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).

ProductInfo

CasNo.	54965-24-1
Purity	≥98%
Formula	C₂₆H₂₉NO•C₆H₈O₇
FormulaWt.	563.64
ChemicalName	(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylaminecitrate
IUPACName	2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylicacidInChI:InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
Synonym	Kessar;Nolvadex;Taxus;Zynoplex;Zemide
MeltingPoint	143-146°C
Solubility	Slightlysolubleinwater.Solubleinethanol,methanoloracetone.
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	T0250MSDSPDF
InfoSheet	T0250InfoSheetPDF

References

YildizA,GuleryuzS,AnkerstDP,etal.ProteinkinaseCinhibitioninthetreatmentofmania:adouble-blind,placebo-controlledtrialoftamoxifen.ArchGenPsychiatry.2008Mar;65(3):255-63.PMID:18316672.

KrumSA,Miranda-CarboniGA,HauschkaPV,etal.EstrogenprotectsbonebyinducingFasligandinosteoblaststoregulateosteoclastsurvival.EMBOJ.2008Feb6;27(3):535-45.PMID:18219273.

SteinerAZ,TerplanM,PaulsonRJ.Comparisonoftamoxifenandclomiphenecitrateforovulationinduction:ameta-analysis.HumReprod.2005Jun;20(6):1511-5.PMID:15845599.

BlackwellKL,HaroonZA,ShanS,etal.Tamoxifeninhibitsangiogenesisinestrogenreceptor-negativeanimalmodels.ClinCancerRes.2000Nov;6(11):4359-64.PMID:11106254.

JordanVC.FourteenthGaddumMemorialLecture.Acurrentviewoftamoxifenforthetreatmentandpreventionofbreastcancer.BrJPharmacol.1993Oct;110(2):507-17.PMID:8242225.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂