LKT/丹参酮I/T0153/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/丹参酮I/T0153/10 mg

LKT/丹参酮I/T0153/10 mg

商品编号： T0153-10mg

品牌： lktlabs

市场价： ¥2080.00

美元价： 1248.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID T0153

Cas No. 568-73-0

Purity ≥95%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Tanshinone I is a diterpene found in Salvia that exhibits neuroprotective, anti-inflammatory, antioxidative, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. Tanshinone I upregulates expression of IL-4 and IL-13, protecting against cerebral ischemia/reperfusion-induced injury in vivo. Tanshinone I also decreases peroxynitrite-induced DNA damage and radical formation. Additionally, tanshinone I inhibits expression of VEGF, cyclin A, cyclin B, and AurA in various models of lung cancer, inhibiting cellular and tumor growth.

Product Info

Cas No.	568-73-0
Purity	≥95%
Formula	C₁₈H₁₂O₃
Formula Wt.	276.29
Chemical Name	1,6-Dimethylphenanthro(1,2-b)furan-10,11-dione
IUPAC Name	1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione
Synonym	Tanshinone A
Melting Point	233-234°C
Solubility	Soluble in DMSO.
Appearance	Dark purple crystal

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	T0153 MSDS PDF
Info Sheet	T0153 Info Sheet PDF

References

Park JH, Park OK, Cho JH, et al. Anti-inflammatory Effect of Tanshinone I in Neuroprotection Against Cerebral Ischemia-Reperfusion Injury in the Gerbil Hippocampus. Neurochem Res. 2014 Apr 24. [Epub ahead of print]. PMID: 24760430.

Zhou S, Chen W, Su H, et al. Protective properties of tanshinone I against oxidative DNA damage and cytotoxicity. Food Chem Toxicol. 2013 Dec;62:407-12. PMID: 24021569.

Tung YT, Chen HL, Lee CY, et al. Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions. Evid Based Complement Alternat Med. 2013;2013:319247. PMID: 23662128.

Tao S, Zheng Y, Lau A, et al. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal. 2013 Nov 10;19(14):1647-61. PMID: 23394605.

Li Y, Gong Y, Li L, et al. Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. Mol Carcinog. 2013 Jul;52(7):535-43. PMID: 22389266.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Zhang Y, Won SH, Jiang C, et al. Tanshinones fmor Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012 Jun;29(6):1595-1608. PMID: 22281759.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂