LKT/TDZD-8/T1298/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/TDZD-8/T1298/250 mg

LKT/TDZD-8/T1298/250 mg

商品编号： T1298-250mg

品牌： lktlabs

市场价： ¥19460.00

美元价： 11676.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDT1298

CasNo.327036-89-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

TDZD-8isaninhibitorofglycogensynthasekinase3β(GSK-3β)thatexhibitsanti-inflammatory,anti-arthritic,andneuroprotectiveactivities.TDZD-8preventshemorrhagicshock-inducedchangesinlivermicrocirculationandhepatocellularinjury,inhibitingtheinflammatoryresponseandimprovingliverfunctioninvivo.Inrheumatoidarthritissynoviocytes,TDZD-8decreaseslevelsofp38MAPK,ATF-2,c-jun,andJNK;inmatchedanimalmodels,thiscompounddecreasescollagen-inducedarthritisbyinhibitinginfiltrationofTcellsandmacrophagesaswellasdecreasinglevelsofIL-1β,IL-6,TNF-α,andIFN-γ.Inotheranimalmodels,TDZD-8improvesdeficitsinspontaneousalternationintheY-mazeandchangesinlocomotoractivityinducedbyamphetaminesandviral-likeimmuneactivation.

ProductInfo

CasNo.	327036-89-5
Purity	≥98%
Formula	C₁₀H₁₀N₂O₂S
FormulaWt.	222.26
ChemicalName	4-Benzyl-2-methyl-1,2,4-thiADIazolidine-3,5-dione
IUPACName	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
MeltingPoint	63-64.4°C
Solubility	SolubleinDMSO(18mg/mL).
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	T1298InfoSheetPDF

References

JellestadL,FinkT,PradaruttiS,etal.Inhibitionofglycogensynthasekinase(GSK)-3-βimproveslivermicrocirculationandhepatocellularfunctionafterhemorrhagicshock.EurJPharmacol.2014Feb5;724:175-84.PMID:24389157.

KwonYJ,YoonCH,LeeSW,etal.Inhibitionofglycogensynthasekinase-3βsuppressesinflammatoryresponsesinrheumatoidarthritisfibroblast-likesynoviocytesandcollagen-inducedarthritis.JointBoneSpine.2013Oct28.[Epubaheadofprint].PMID:24176738.

WilliR,HarmeierA,GiovanoliS,etal.AlteredGSK3βsignalinginaninfection-basedmousemodelofdevelopmentalneuropsychiatricdisease.Neuropharmacology.2013Oct;73:56-65.PMID:23707483.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂