TelbivudineisanantiviralandimmunomodulatorycompoundthatiscommonlyusedtotreatchronichepatitisBinfections.TelbivudineistheL-isomerofthymidineandactsasanucleosideanalog.Clinically,telbivudineincreasesexpressionofCD127onCD8+memoryTcells;thiscompoundalsodecreaseshepatitisBviralDNAandnormalizeslevelsofalanineaminotransferase.
| CasNo. | 3424-98-4 |
|---|---|
| Purity | ≥98% |
| Formula | C10H14N2O5 |
| FormulaWt. | 242.23 |
| IUPACName | 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| Synonym | Epavudine,L-Thymidine,1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracilβ-L-2-deoxythymidineβ-L-thymidine(LdT)1-[(2S,4R,5S)-4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T1844InfoSheetPDF |
|---|
NanXP,ZhangY,YuHT,etal.InhibitionofviralreplicationdownregulatesCD4(+)CD25(high)regulatoryTcellsandprogrammeddeath-ligand1inchronichepatitisB.ViralImmunol.2012Feb;25(1):21-8.PMID:22233255.
LvG,YingL,MaWJ,etal.DynamicanalysisofCD127expressiononmemoryCD8TcellsfrompatientswithchronichepatitisBduringtelbivudinetreatment.VirolJ.2010Aug31;7:207.PMID:20807412.
LaiCL,LeungN,TeoEK,etal.A1-yeartrialoftelbivudine,lamivudine,andthecombinationinpatientswithhepatitisBeantigen-positivechronichepatitisB.Gastroenterology.2005Aug;129(2):528-36.PMID:16083710.
