Description
Thymosinα-1isanendogenousimmunostimulatorypeptidethatisusedtotreatimmunedeficiencydiseasesandtoenhancevaccineimmunogenicity.Thymosinα-1enhancesT-cell,dendriticcell,andantibodyresponsesinvitroandinhibitssteroid-inducedthymocyteapoptosis.Duringtransplants,thymosinα-1activatesindoleamine2,3-dioxygenase,promotingimmunetolerance.Invitro,thispeptidemodulatesCD4+CD25+Foxp3+Tregcellsandpro-inflammatorycytokinelevels.
References
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