TM3-0089isaninhibitorofchemoattractantreceptor-homologousmoleculeonTh4cells(CRTH2),whichinhibitsprostaglandinactivationofTh4cells.TM3-0089exhibitsanti-allergicandanti-inflammatoryactivities.TM3-0089preventsmigrationofTh4lymphocytes,calciuminflux,andadhesionoflymphocytestovascularendothelialcellsinvitro.
| Purity | ≥98% |
|---|---|
| Formula | C21H20FN2O4SNa•H2O |
| FormulaWt. | 456.46 |
| Synonym | CAY10471 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T4800InfoSheetPDF |
|---|
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SchröderR,XueL,KonyaV,etal.PGH1,theprecursorfortheanti-inflammatoryprostaglandinsofthe1-series,isapotentactivatorofthepro-inflammatoryreceptorCRTH2/DP2.PLoSOne.2012;7(3):e33329.PMID:22442685.
UllerL,MathiesenJM,AlenmyrL,etal.AntagonismoftheprostaglandinD2receptorCRTH2attenuatesasthmapathologyinmouseeosinophilicairwayinflammation.RespirRes.2007Feb28;8:16.PMID:17328802.
