DomperidoneisanantagoNISTatD2/3receptorsthatisclinicallyusedtotreatnausea,induceprolactinrelease,andincreasegastrointestinaltransitspeed.Domperidoneexhibitsantiemetic,antinociceptive,analgesic,andprokineticgastrointestinalmotilitymodulatingactivities.Inanimalsundergoingtheformalintest,domperidonedecreasesoverallpainscore.Domperidonealsoinhibitshumanether-a-go-go-related(hERG)K+channelcurrents,prolongingtheQTinterval.
| CasNo. | 57808-66-9 |
|---|---|
| Purity | ≥98% |
| Formula | C22H24ClN5O2 |
| FormulaWt. | 425.91 |
| ChemicalName | 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one |
| IUPACName | 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one |
| Synonym | Euciton;Evoxin;Mod;Motilium;Nnauzelin:Peridon;Peridys |
| MeltingPoint | 242.5°C |
| Solubility | Slightlysolubleinwater(0.986mg/L).solubleindimethylformamide,slightlysolubleinalcoholandinmethanol |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | D5649MSDSPDF |
|---|---|
| InfoSheet | D5649InfoSheetPDF |
ClaassenS,ZünklerBJ.ComparisonoftheeffectsofmetoclopramideanddomperidoneonHERGchannels.Pharmacology.2005Apr;74(1):31-6.PMID:15640612.
SivasankerM,ReddyPM,ShashindranCH,etal.Formalinassayparametersdifferinconfirmingtheantinociceptivemechanismofdomperidoneinmice.IndianJExpBiol.2004Apr;42(4):429-31.PMID:15088695.
