LKT/DOXEPIN HYDROCHLORIDE/D5994/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/DOXEPIN HYDROCHLORIDE/D5994/1 g

LKT/DOXEPIN HYDROCHLORIDE/D5994/1 g

商品编号： D5994-1g

品牌： lktlabs

市场价： ¥880.00

美元价： 528.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDD5994

CasNo.1229-29-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Doxepinhydrochlorideisatricyclicantidepressantthatalsoexhibitsanxiolytic,analgesic,anti-ulcerative,andhypnoticactivities.Thiscompounddisplaysinhibitoryactivityatawiderangeofreceptorsubtypes,including5-HT1/2receptors,muscarinicacetylcholinereceptors(M1-5mAChRs),α1-adrenergicreceptors,andhistamine(H1/2)receptors;additionally,doxepinhydrochloridecompetitivelyantagonizestheSEROtonintransporter(SERT)andthenorepinephrinetransporter(NET).Doxepinhydrochlorideismostoftenprescribedasanorallybioavailabletreatmentfordepression,anxiety,insomnia,orwhentopicallyapplied,dermatologicalitch.Inadditiontoitsmodulationofneurotransmitterlevels,doxepinhydrochloridealsoinhibitstheH+/K+ATPasethroughK+antagonismandintravesicularneutralization;likeotherantidepressants,thiscompoundalsoregulatesHPAaxissignaling,decreasingstress-inducedcorticosteronerelease,potentiallythroughanendocannABInoid-mediatedsignalingpathway.Doxepinalsoactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).

ProductInfo

CasNo.	1229-29-4
Purity	≥98%
Formula	C₁₉H₂₁NO•HCl
FormulaWt.	315.84
IUPACName	3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	D5994InfoSheetPDF

References

HassanzadehP,HassanzadehA.TheRoleoftheEndocannabinoidsinSuppressionoftheHypothalamic-pituitary-adrenalAxisActivitybyDoxepin.IranJBasicMedSci.2011Sep;14(5):414-21.PMID:23493814.

ChengBC,ChanBR,ChenYW,etal.Doxepinhasapotentandlong-actingspinalanestheticeffectinrats.KaohsiungJMedSci.2006Feb;22(2):68-74.PMID:16568723.

HajakG,RodenbeckA,VoderholzerUetal.Doxepininthetreatmentofprimaryinsomnia:aplacebo-controlled,double-blind,polysomnographicstudy.JClinPsychiatry.2001Jun;62(6):453–63.PMID:11465523.

FigueiredoA,RibeiroCA,GonçaloM,etal.Mechanismofactionofdoxepininthetreatmentofchronicurticaria.FundamClinPharmacol.1990;4(2):147-58.PMID:2141000.

BeilW,StaarU,SchünemannP,etal.Omeprazole,SCH28080anddoxepindifferintheircharacteristicstoinhibitH+/K+-ATPasedrivenprotonaccumulationbyparietalcellmembranevesicles.BiochemPharmacol.1988Dec1;37(23):4487-93.PMID:2849447.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂