LKT/ELLAGIC ACID/E4444/50 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/ELLAGIC ACID/E4444/50 g

LKT/ELLAGIC ACID/E4444/50 g

商品编号： E4444-50g

品牌： lktlabs

市场价： ¥12260.00

美元价： 7356.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDE4444

CasNo.476-66-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Ellagicacidisaphenolfoundinvariousfruitsthatexhibitsneuroprotective,anti-angiogenic,anti-inflammatory,anti-asthma,anti-allergic,antiviral,antioxidative,anti-parasitic,antimalarial,anticancer,andanti-ulcerativeactivities.EllagicacidinhibitsHIF-1α-inducedPI3K/AktandVEGF/VEGFR2signaling,downregulatesexpressionofHDAC6,andsuppressesneovascularizationandangiogenesisinvitroandinvivo.InanimalmodelsofOVA-inducedallergy,ellagicaciddecreaseseosinophilinfiltration,Th4cytokinerelease,IgElevels,andNF-κBactivation,preventingairwayhyperresponsiveness.Invitro,ellagicacidupregulatesexpressionofHDAC9anddecreasesdifferentiationofADIpocytes.ThiscompoundinhibitsproliferationofPlasmodiumandRhinovirus.Inanimalmodelsofinflammation,ellagicacidincreaseslevelsofglutathioneandIL-10anddecreaseslevelsofNO,maldionaldehyde,IL-1β,TNF-α,COX-2,andNF-κB.Inpancreaticadenocarcinomacells,thiscompoundsuppressescellularproliferationandinducesapoptosis.Ellagicacidalsoinhibitstheformationofulcersinanimalmodels.

ProductInfo

CasNo.	476-66-4
Purity	≥98%
Formula	C₁₄H₆O₈
FormulaWt.	302.20
ChemicalName	2,3,7,8-Tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
Synonym	Benzoaricacid;Lagistase.
MeltingPoint	>300°C
Solubility	Veryslightlysolubleinwater.Solublein1NNaOH(10mg/mL).
Appearance	Brown/YellowSolid

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	E4444MSDSPDF
InfoSheet	E4444InfoSheetPDF

References

ZhouE,FuY,WeiZ,etal.InhibitionofallergicairwayinflammationthroughtheblockageofNF-κBactivationbyellagicacidinanovalbumin-inducedmouseasthmamodel.FoodFunct.2014Sep;5(9):2106-12.PMID:24998475.

KangI,OklaM,ChungS.Ellagicacidinhibitsadipocytedifferentiationthroughcoactivator-associatedargininemethyltransferase1-mediatedchromatinmodification.JNutrBiochem.2014Sep;25(9):946-53.PMID:24929439.

KowshikJ,GiriH,KiranKishoreTK,etal.EllagicAcidInhibitsVEGF/VEGFR2,PI3K/AktandMAPKSignalingCascadesintheHamsterCheekPouchCarcinogenesisModel.AnticancerAgentsMedChem.2014Jul23.[Epubaheadofprint].PMID:25060902.

ParkSW,KwonMJ,YooJY,etal.AntiviralactivityandpossIBLemodeofactionofellagicacididentifiedinLagerstroemiaspeciosaleavestowardhumanrhinoviruses.BMCComplementAlternMed.2014May26;14:171.PMID:24885569.

El-ShitanyNA,El-BastawissyEA,El-desokyK.Ellagicacidprotectsagainstcarrageenan-inducedacuteinflammationthroughinhibitionofnuclearfactorkappaB,induciblecyclooxygenaseandproinflammatorycytokinesandenhancementofinterleukin-10viaanantioxidantmechanism.IntImmunopharmacol.2014Apr;19(2):290-9.PMID:24534771.

NjomnangSohP,WitkowskiB,GalesA,etal.Implicationofglutathioneintheinvitroantiplasmodialmechanismofactionofellagicacid.PLoSOne.2012;7(9):e45906.PMID:23029306.

BeserraAM,CalegariPI,SouzaMdoC,etal.Gastroprotectiveandulcer-healingmechanismsofellagicacidinexperimentalrats.JAgricFoodChem.2011Jul13;59(13):6957-65.PMID:21644797

FengY,YangSG,DuXT,etal.EllagicacidpromotesAbeta42fibrillizationandinhibitsAbeta42-inducedneurotoxicity.BiochemBiophysResCommun.2009Dec25;390(4):1250-4.PMID:19878655.

EdderkaouiM,OdinokovaI,OhnoI,etal.EllagicacidinducesapoptosisthroughinhibitionofnuclearfactorkappaBinpancreaticcancercells.WorldJGastroenterol.2008Jun21;14(23):3672-80.PMID:18595134.

ZhaoM,TangSN,MarshJL,etal.EllagicacidinhibitshumanpancreaticcancergrowthinBalbcnudemice.CancerLett.2013Sep1;337(2):210-217.PMID:23684930.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂