LKT/EPIGALLOCATECHIN GALLATE/E6234/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/EPIGALLOCATECHIN GALLATE/E6234/25 mg

LKT/EPIGALLOCATECHIN GALLATE/E6234/25 mg

商品编号： E6234-25mg

品牌： lktlabs

市场价： ¥1140.00

美元价： 684.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDE6234

CasNo.989-51-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Epigallocatechingallate(EGCG)isaflavonoid(flavanol)foundinCamilla(greentea);itisoneofseveralgreenteacatechins.EGCGexhibitsneuroprotective,antioxidative,anti-inflammatory,anti-diabetic,antifungal,anti-metastatic,andanticancerchemotherapeuticactivities.EGCGdirectlyinhibitsSTAT3andthearylhydrocarbonreceptor.EGCGinhibitsα-synucleinoligomerizationinmodelsofParkinson’sdiseaseandlimitsamyloid-β(Aβ)aggregationinmodelsofAlzheimer’sdisease.Inanimalmodelsofautoimmunesialadenitis,EGCGinhibitsROS-mediatedDNAdamageandoxidativestressandincreaseslevelsofhemeoxygenase1(HO-1)andBcl-2.Additionally,EGCGdecreaseslevelsoftoll-likereceptor4(TLR4),IKKβ,activatedNF-κB,TNF-α,CD68,andIL-6,suppressesmacrophageinfiltration,increaseslevelsofPI3KandGLUT4,inhibitsα-amylaseandα-glucosidase,andimprovesinsulinsignalinginanimalmodelsofdiabetes.Inhepatocarcinomacells,thiscompoundinducesS-phasecellcyclearrestandapoptosisanddecreaseslevelsofPI3K,Akt,andNF-κB.Inothercellularmodels,EGCGinhibitstheepithelial-to-mesenchymaltransition(EMT)andlimitscellmotility;italsoindirectlyinhibitsEGFR.Inanimalmodelsofbladdercancer,EGCGdecreasestumorgrowth.ThiscompoundalsoinducesapoptosisinCandida.EGCGdirectlyinhibitsHSP90inanimalmodelsofprostatecancer,decreasingtumorsizeandprogression.

ProductInfo

CasNo.	989-51-5
Purity	≥98%
Formula	C₂₂H₁₈O₁₁
FormulaWt.	458.37
ChemicalName	3,4,5-Trihydroxybenzoicacid,(2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl
IUPACName	[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl]3,4,5-trihydroxybenzoate
Synonym	(-)-Epigallocatechingallate;EGCG;3-O-gallate
MeltingPoint	218°C
Solubility	Solubleinmethanol,ethnol(92mg/mL)orDMSO(92mg/mL).Slightlysolubleinwater.
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	E6234MSDSPDF
InfoSheet	E6234InfoSheetPDF
Brochures	GreenTeaFlyer
	NaturalProductsFlyer
	JAK/STATFlyer

References

MosesMA,HenryEC,RickeWA,etal.Theheatshockprotein90inhibitor,(-)-epigallocatechingallate,hasanticanceractivityinanovelhumanprostatecancerprogressionmodel.CancerPrevRes(Phila).2015Mar;8(3):249-57.PMID:25604133.

LorenzenN,NielsenSB,YoshimuraY,etal.Howepigallocatechingallatecaninhibitα-synucleinoligomertoxicityinvitro.JBiolChem.2014Aug1;289(31):21299-310.PMID:24907278.

BaoS,CaoY,FanC,etal.Epigallocatechingallateimprovesinsulinsignalingbydecreasingtoll-likereceptor4(TLR4)activityinADIposetissuesofhigh-fatdietrats.MolNutrFoodRes.2014Apr;58(4):677-86.PMID:24259392

ShenX,ZhangY,FengY,etal.Epigallocatechin-3-gallateinhibitscellgrowth,inducesapoptosisandcausesSphasearrestinhepatocellularcarcinomabysuppressingtheAKTpathway.IntJOncol.2014Mar;44(3):791-6.PMID:24402647.

daSilvaCR,deAndradeNetoJB,deSousaCamposR,etal.Synergisticeffectoftheflavonoidcatechin,quercetin,orepigallocatechingallatewithfluconazoleinducesapoptosisinCandidatropicalisresistanttofluconazole.AntimicrobAgentsChemother.2014;58(3):1468-78.PMID:24366745.

MaYC,LiC,GaoF,etal.EpigallocatechingallateinhibitsthegrowthofhumanlungcancerbydirectlytargetingtheEGFRsignalingpathway.OncolRep.2014Mar;31(3):1343-9.PMID:24366444.

SaitoK,MoriS,DateF,etal.Epigallocatechingallateinhibitsoxidativestress-inducedDNAdamageandapoptosisinMRL-Fas(lpr)micewithautoimmunesialadenitisviaupregulationofhemeoxygenase-1andBcl-2.Autoimmunity.2014Feb;47(1):13-22.PMID:24392721.

TakahashiA,WatanabeT,MondalA,etal.Mechanism-basedinhibitionofcancermetastasiswith(-)-epigallocatechingallate.BiochemBiophysResCommun.2014Jan3;443(1):1-6.PMID:24269590.

JankunJ,KeckRW,SelmanSH.Epigallocatechin-3-gallatepreventstumorcellimplantation/growthinanexperimentalratbladdertumormodel.IntJOncol.2014Jan;44(1):147-52.PMID:24220494.

WangY,RenX,DengC,etal.MechanismoftheinhibitionoftheSTAT3signalingpathwaybyEGCG.OncolRep.2013Dec;30(6):2691-6.PMID:24065300.

BleiholderC,DoTD,WuC,etal.IonmobilityspectrometryrevealsthemechanismofamyloidformationofAβ(25-35)anditsmodulationbyinhibitorsatthemolecularlevel:epigallocatechingallateandscyllo-inositol.JAmChemSoc.2013Nov13;135(45):16926-37.PMID:24131107.

GaoJ,XuP,WangY,etal.Combinedeffectsofgreenteaextracts,greenteapolyphenolsorepigallocatechingallatewithacarboseoninhibitionagainstα-amylaseandα-glucosidaseinvitro.Molecules.2013Sep18;18(9):11614-23.PMID:24051476.

YuJ,JiaY,GuoY,etal.Epigallocatechin-3-gallateprotectsmotorneuronsandregulatesglutamatelevel.FEBSLett.2010Jul2;584(13):2921-2925.PMID:20488180.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂