Description
EsculinisacoumaringlucosidefoundinAesculus,Daphne,andBursaria.Esculinexhibitsanti-diabeticandantioxidativeactivities.EsculinishydrolyzedbyspeciesofStreptococcus,Enterococcus,Listeria,andAerococcusandisusedinresearchmodelstoidentifythesebacteria.Indiabeticrats,esculindecreasesbloodglucoseandglucose-6-phosphataselevelsandincreasesglucoseuptake,potentiallythroughtheactivationofinsulinreceptors,Akt,andGSK3β.Additionally,esculindecreaseslipidperoxidationandincreaseslevelsofglutathione,glutathioneperoxidase,glutathione-S-transferase,superoxidedismutase,andcatalaseinthekidneysofanimalstreatedwithpro-oxidantaflatoxinB1.