LKT/EVODIAMINE/E8657/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/EVODIAMINE/E8657/250 mg

LKT/EVODIAMINE/E8657/250 mg

商品编号： E8657-250mg

品牌： lktlabs

市场价： ¥2980.00

美元价： 1788.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDE8657

CasNo.518-17-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

EvodiamineisanindolealkaloidoriginallyfoundinEvodiarutaecarpa.Thiscompoundexhibitsanticancer,anti-diabetic,antiviral,anti-angiogenic,andgastrointestinalmotilitymodulatingactivities.Inbladdercancercells,evodiaminedecreaseslevelsofMcl-1,inhibitssignalingofmTOR,andenhancesTRAIL-inducedapoptosis.EvodiaminedirectlyinhibitstopoisomerasesIandII(topoI,topoII),inducingG2/Mphasecellcyclearrestinleukemiacells.Inotherinvitromodels,evodiaminedecreasesVEGFreleaseandtubeformation.Indiabetic/obeseanimalmodels,evodiaminedecreasesmTORsignalingandincreasesphosphorylationofAMPK,improvingglucosetolerance.Additionally,thiscompoundinhibitsviralreplicationofInfluenzaAandsuppressesgastricemptyingandtransit.

ProductInfo

CasNo.	518-17-2
Purity	≥98%
Formula	C₁₉H₁₇N₃O
FormulaWt.	303.36
MeltingPoint	265-278°C
Appearance	LightYellowFinePowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	E8657InfoSheetPDF

References

ZhangT,QuS,ShiQ,etal.EvodiamineInducesApoptosisandEnhancesTRAIL-InducedApoptosisinHumanBladderCancerCellsthroughmTOR/S6K1-MediatedDownregulationofMcl-1.IntJMolSci.2014Feb21;15(2):3154-71.PMID:24566141.

WangT,KusudoT,TakeuchiT,etal.Evodiamineinhibitsinsulin-stimulatedmTOR-S6KactivationandIRS1serinephosphorylationinADIpocytesandimprovesglucosetoleranceinobese/diabeticmice.PLoSOne.2013Dec31;8(12):e83264.PMID:24391749.

DaiJP,LiWZ,ZhaoXF,etal.AdrugscreeningmethodbasedontheautophagypathwayandstudiesofthemechanismofevodiamineagainstinfluenzaAvirus.PLoSOne.2012;7(8):e42706.PMID:22900043.

PanX,HartleyJM,HartleyJA,etal.Evodiamine,adualcatalyticinhibitoroftypeIandIItopoisomerases,exhibitsenhancedinhibitionagainstcamptothecinresistantcells.Phytomedicine.2012May15;19(7):618-24.PMID:22402246.

ShyuKG,LinS,LeeCC,etal.Evodiamineinhibitsinvitroangiogenesis:Implicationforantitumorgenicity.LifeSci.2006Apr4;78(19):2234-43.PMID:16280136.

WuCL,HungCR,ChangFY,etal.Effectsofevodiamineongastrointestinalmotilityinmalerats.EurJPharmacol.2002Dec20;457(2-3):169-76.PMID:12464363.

SungB,PrasadS,RavindranJ,etal.Capsazepine,aTRPV1antagoNIST,sensitizescolorectalcancercellstoapoptosisbyTRAILthroughROS-JNK-CHOP-mediatedupregulationofdeathreceptors.FreeRadicBiolMed.2012Nov15;53(10):1977-1987.PMID:22922338.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂