FamotidineisanantagoNISTathistamineH2receptorsthatexhibitsantacidandantioxidativeactivities.Famotidineinhibitsgastricacidproductionandisclinicallyusedtotreatulcersandgastroesophagealrefluxdisease(GERD).FamotidinealsoinhibitsGSK-3βandsuppressesrADIation-inducedDNAdamage.
| CasNo. | 76824-35-6 |
|---|---|
| Purity | ≥98% |
| Formula | C8H15N7O2S3 |
| FormulaWt. | 337.45 |
| ChemicalName | 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]-methyl]thio-N-(aminosulfonyl)propanimidamide |
| IUPACName | 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N"-sulfamoylpropanimidamide |
| Synonym | Amfamox;Dispromil;Famodine;Fanosin;Gaster;Motiax;Pepcid;Ulcetrax |
| MeltingPoint | 163-164°C |
| Solubility | Insolubleinwater.SolubleinDMF. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | F0150MSDSPDF |
|---|---|
| InfoSheet | F0150InfoSheetPDF |
MohammadM,Al-MasriIM,IssaA,etal.Famotidineinhibitsglycogensynthasekinase-3β:aninvestigationbydockingsimulationandexperimentalvalidation.JEnzymeInhibMedChem.2013Aug;28(4):690-4.PMID:22512725.
MozdaraniH,NasirianB,HaeriSA.Invivogamma-raysinducedinitialDNAdamageandtheeffectoffamotidineinmouseleukocytesasassayedbythealkalinecometassay.JRadiatRes.2007Mar;48(2):129-34.PMID:17299251.
