FlavokawainAisachalconekavalactoneoriginallyfoundinPipermethysticum(kavaplant).FlavokawainAexhibitsanti-inflammatoryandanticancerchemotherapeuticactivities.ThiscompoundinhibitsdegradationofIκBαandactivationofNF-κB;italsoinhibitsexpressionofiNOSandCOX-2inmacrophagesaswellasactivityofIκK,PRAK,MAPKAP-K3,DYRK1A,andAurB.Invivo,flavokawainAinhibitsurothelialcellcarcinoma,decreasingexpressionofKi67,XIAP,andsurvivin,andincreasingexpressionofDR5andp27.
| CasNo. | 64680-84-8 |
|---|---|
| Purity | ≥98% |
| Formula | C18H18O5 |
| FormulaWt. | 314.33 |
| IUPACName | 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one |
| MeltingPoint | 112-116°C |
| Solubility | DMSO100mM.Insolubleinwater.Solubleinmethanol. |
| Appearance | Yellowcrystallinepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | F4502MSDSPDF |
|---|---|
| InfoSheet | F4502InfoSheetPDF |
LiuZ,XuX,LiX,etal.Kavachalcone,flavokawainA,inhibitsurothelialtumOrigenesisintheUPII-SV40Ttransgenicmousemodel.CancerPrevRes(Phila).2013Dec;6(12):1365-75.PMID:24121102.
KwonDJ,JuSM,YounGS,etal.SuppressionofiNOSandCOX-2expressionbyflavokawainAviablockadeofNF-κBandAP-1activationinRAW264.7macrophages.FoodChemToxicol.2013Aug;58:479-86.PMID:23727179.
FolmerF,BlasiusR,MorceauF,etal.InhibitionofTNFalpha-inducedactivationofnuclearfactorkappaBbykava(Pipermethysticum)derivatives.BiochemPharmacol.2006Apr14;71(8):1206-18.PMID:16464438.
