Description
Gallocatechingalleate(GCG)isapolyphenoloriginallyderivedfromavarietyofsources,includinggreentea,coffee,safflower,andalmonds.GCGexhibitsawidevarietyofbeneficialproperties,includinganti-diabetic,anti-osteoporotic,antiviral,anti-parasitic,andanticancerchemotherapeuticactivities.GCGinhibitsamyloidformationbyisletamyloidpolypeptide(amylin)andalsoinhibitsglutathione-S-transferaseincellularmodels.GCGinhibitsHIVintegrase,preventingitsABIlitytobindtoDNA.Separately,thiscompoundpreventshatchingofnematodesinvivo.GCGalsohaspositiveeffectsonbonemetabolism,decreasingosteoclastogenesisandinhibitingosteoclastdifferentiation.
References
MaslerEP.Effectsofcatechinpolyphenolsandpreparationsfromtheplant-parasiticnematodeHeteroderaglycinesonproteaseactivityandbehaviourinthreenematodespecies.JHelminthol.2013May2:1-8.[Epubaheadofprint].PMID:23635519.
TimmelMA,BylJA,OsheroffN.EpimerizationofGreenTeaCatechinsduringBrewingDoesNotAffecttheAbilitytoPoisonHumanTypeIITopoisomerases.ChemResToxicol.2013Apr4.[Epubaheadofprint].PMID:23514406.
BoušováI,HájekJ,DršataJ,etal.NaturallyoccurringflavonoidsasinhibitorsofpurifiedcytosolicglutathioneS-transferase.Xenobiotica.2012Sep;42(9):872-9.PMID:22458346.
CaoP,RaleighDP.Analysisoftheinhibitionandremodelingofisletamyloidpolypeptideamyloidfibersbyflavanols.Biochemistry.2012Apr3;51(13):2670-83.PMID:22409724.
JiangF,ChenW,YiK,etal.TheevaluationofcatechinsthatcontainagalloylmoietyaspotentialHIV-1integraseinhibitors.ClinImmunol.2010Dec;137(3):347-56.PMID:20832370.
KoCH,LauKM,ChoyWY,etal.Effectsofteacatechins,epigallocatechin,gallocatechin,andgallocatechingallate,onbonemetabolism.JAgricFoodChem.2009Aug26;57(16):7293-7.PMID:19653629.
