Description
Gastrin-releasingpeptide(GRP)isanendogenousbombesin-likepeptidethatstimulatesthereleaseofgastrinbybindingGRPreceptors;itisinvolvedinfeedingbehavior(actingasananorexigenic),circADIanrhythms,andstresssignaling.GRPinducesscratchingbehaviorinvivoandexhibitspro-angiogenicactivityincancermodels,inducingexpressionofIL-8inahepatocytegrowthfactor-dependentmanneringastriccancercells.
References
KallingalGJ,MintzEM.Site-specificeffectsofgastrin-releasingpeptideinthesuprachiasmaticnucleus.EurJNeurosci.2014Feb;39(4):630-9.PMID:24528136.
LeeKH,KohSA,KimJR.Hepatocytegrowthfactor-mediatedgastrin-releasingpeptideinducesIL-8expressionthroughEts-1ingastriccancercells.OncolRes.2013;20(9):393-402.PMID:23924923.
SukhtankarDD,KoMC.Physiologicalfunctionofgastrin-releasingpeptideandneuromedinBreceptorsinregulatingitchscratchingbehaviorinthespinalcordofmice.PLoSOne.2013Jun24;8(6):e67422.PMID:23826298.
MeraliZ,McIntoshJ,AnismanH.Roleofbombesin-relatedpeptidesinthecontroloffoodintake.Neuropeptides.1999Oct;33(5):376-86.PMID:10657515.