Description
GastrinisanendogenouspeptidehormonethatactsasanagoNISTatthecholestocystokinin2(CCK2)receptor,exhibitinganorexigenicandgastrointestinalmotilitymodulatingactivities.Gastrininhibitsfoodintakeandslowsgastricemptying,constrictingthepyloricsphincterinvivo.Additionally,gastrinincreasesreleaseofhistamineandinducesmembranetranslocationoftheH+/K+ATPase,stimulatinggastricacidrelease.
References
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RattanS,ColnD,GoyalRK.Themechanismofactionofgastrinontheloweresophagealsphincter.Gastroenterology.1976May;70(5PT.1):828-31.PMID:1261781.