Description
GinkgolicacidsarefoundinGinkgobilobaandexhibitantiviral,antibiotic,andanticancerchemotherapeuticactivities.Invitro,ginkgolicacidsinhibitHIVproteaseandsuppressHIVinfection.Ginkgolicacidsalsoexhibitantibacterialactivityagainstbothgrampositiveandgramnegativebacteria,includingStaphylococcus,Escherichia,andBacillus.Ginkgolicacidsalsoinhibitfattyacidsynthaseandexhibitcytotoxicityinbreastcancer,lungcancer,andleukemiacells.Additionally,ginkgolicacidsinduceapoptosisincancercellsthroughdownregulationofBcl-2andupregulationofBax.Ginkgolicacidsmayalsobeneurotoxic,astheyincreaseactivityofproteinphosphatase2C(PP2C)inneurons.
References
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