Ginkgolide J is a terpene lactone found in Ginkgo biloba. Ginkgolide J exhibits neuroprotective and antioxidative activities. Ginkgolide J prevents amyloid-β (Aβ)-induced cell death in cellular models of Alzheimer’s disease. In other cellular models, ginkgolide J inhibits the formation of superoxide and hydroperoxyl radicals.
| Cas No. | 107438-79-9 |
|---|---|
| Purity | ≥98% |
| Formula | C20H24O10 |
| Formula Wt. | 424.40 |
| Solubility | Insoluble in water. Soluble in DMSO. |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | G3359 Info Sheet PDF |
|---|
Vitolo O, Gong B, Cao Z, et al. Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. Neurobiol Aging. 2009 Feb;30(2):257-65. PMID: 17640772.
Ahlemeyer B, Krieglstein J. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry. 2003 Jun;36 Suppl 1:S8-14. PMID: 13130383.
Scholtyssek H, Damerau W, Wessel R, et al. Antioxidative activity of ginkgolides against superoxide in an aprotic environment. Chem Biol Interact. 1997 Oct 24;106(3):183-90. PMID: 9413545.
