Description
Ginsenoside Rb1 is a triterpene saponin originally found in species of Panax that exhibits antioxidative, anti-inflammatory, neuroprotective, orexigenic, and stimulatory activities. In animal models, ginsenoside Rb1 increases motor activity, food intake, and skeletal muscle ATP content, improving energy metabolism. Ginsenoside Rb1 also downregulates expression of toll-like receptor 4 (TLR4) and TNF-α in animal models of sepsis, protecting against liver and lung damage. Additionally, ginsenoside Rb1 inhibits glucose-induced neurotoxicity by preventing GSK-3β-stimulated CHOP induction. This compound also activates Nrf2 and increases expression of heme oxygenase 1 (HO-1), suppressing oxidative stress in vitro.
References
Tan SJ, Li N, Zhou F, et al. Ginsenoside Rb1 improves energy metabolism in the skeletal muscle of an animal model of postoperative fatigue syndrome. J Surg Res. 2014 May 2. [Epub ahead of print]. PMID: 24881470.
Wu LL, Jia BH, Sun J, et al. Protective effects of ginsenoside Rb1 on septic rats and its mechanism. Biomed Environ Sci. 2014 Apr;27(4):300-3. PMID: 24758759.
Liu D, Zhang H, Gu W, et al. Ginsenoside Rb1 protects hippocampal neurons from high glucose-induced neurotoxicity by inhibiting GSK3β-mediated CHOP induction. Mol Med Rep. 2014 Apr;9(4):1434-8. PMID: 24535619.
Ni N, Liu Q, Ren H, et al. Ginsenoside Rb1 protects rat neural progenitor cells against oxidative injury. Molecules. 2014 Mar 7;19(3):3012-24. PMID: 24662068.
Xiong Y, Shen L, Liu KJ, et al. Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes. 2010 Oct;59(10):2505-2512. PMID: 20682695.
Shen L, Xiong Y, Wang DQ, et al. Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats. J Lipid Res. 2013 May;54(5):1430-1438. PMID: 23434611.
Lee JS, Song JH, Sohn NW, Shin JW. Inhibitory effects of ginsenoside Rb1 on neuroinflammation fl=ollowing systemic lipopolysaccharide treatment in mice. Phytother Res. 2013 Sep;27(9):1270-1276. PMID: 23042638.
