Description
GinsenosideRcisatriterpenesaponinoriginallyfoundinspeciesofPanaxthatexhibitsantioxidative,anti-aging,antinociceptive,andanti-diabeticactivities.GinsenosideRcinhibitsphosphorylationofFoxo1,inhibitsAMPK,activatesPI3K/Aktsignaling,andincreaseslevelsofcatalase,decreasingoxidativestress.GinsenosideRcalsoinducesantinociceptioninanimalmodelsofwrithingandformalin-inducedpain,potentiallythroughactivityontransientreceptorpotentialvanilloid1(TRPV1)channels.Inotheranimalmodels,ginsenosideRcactivatesAMPKandp38MAPK,increasingglucoseuptake.Additionally,thiscompoundincreasesthelifespanofCaenorhaBDitiselegans.
References
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