Description
Ginsenoside Rc is a triterpene saponin originally found in species of Panax that exhibits antioxidative, anti-aging, antinociceptive, and anti-diabetic activities. Ginsenoside Rc inhibits phosphorylation of Foxo1, inhibits AMPK, activates PI3K/Akt signaling, and increases levels of catalase, decreasing oxidative stress. Ginsenoside Rc also induces antinociception in animal models of writhing and formalin-induced pain, potentially through activity on transient receptor potential vanilloid 1 (TRPV1) channels. In other animal models, ginsenoside Rc activates AMPK and p38 MAPK, increasing glucose uptake. Additionally, this compound increases the life span of Caenorhabditis elegans.
References
Kim DH, Park CH, Park D, et al. Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress. Arch Pharm Res. 2014 Jun;37(6):813-20. PMID: 23918648.
Lee MS, Hwang JT, Kim SH, et al. Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism. J Ethnopharmacol. 2010 Feb 17;127(3):771-6. PMID: 19961916.
Lee JH, Choi SH, Kwon OS, et al. Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans. Biol Pharm Bull. 2007 Nov;30(11):2126-34. PMID: 17978487.
Jung SY, Choi S, Ko YS, et al. Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes. Mol Cells. 2001 Dec 31;12(3):342-6. PMID: 11804333.
Shin YH, Jung OM, Nah JJ, et al. Ginsenosides that produce differential antinociception in mice. Gen Pharmacol. 1999 Jun;32(6):653-9. PMID: 10401990.