LKT/人参皂甙RD/G3456/1 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/人参皂甙RD/G3456/1 mg

LKT/人参皂甙RD/G3456/1 mg

商品编号： G3456-1mg

品牌： lktlabs

市场价： ¥1040.00

美元价： 624.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDG3456

CasNo.52705-93-8

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

GinsenosideRdisatriterpenesaponinoriginallyfoundinspeciesofPanaxthatexhibitsantioxidative,anti-inflammatory,neuroprotective,anticancer,anti-metastatic,cardioprotective,andimmunomodulatoryactivities.GinsenosideRdregulatessecretionofIFNγandIL-4,shiftscytokineproductiontowardTh4phenotype,andincreasesexpressionofBDNFandNGFinanimalmodelsofexperimentalautoimmuneencephalitis(EAE).Inotheranimalmodels,ginsenosideRdpreventspawedemabydecreasingmyeloperoxidaseactivityandmalondialdehydelevels,increasingexpressionofsuperoxidedismutase,glutathioneperoxidase,andcatalase,andinhibitingexpressionofNO,PGE2,iNOS,COX-2,andNF-κB.GinsenosideRddecreasesinfarctsize,cellapoptosis,andlevelsofcreatinekinaseandlactatedehydrogenaseinanimalmodelsofmyocardialischemia/reperfusion.Thiscompoundalsopreventsphosphorylationoftauinanimalmodelsbydecreasingamyloid-β(Aβ)-inducedexpressionandactivityofGSK-3βandstimulatingactivityofproteinphosphatase2A(PP2A).Inhepatocellularcarcinomacells,ginsenosideRdinhibitsinvasionandmigrationbydecreasingexpressionofmatrixmetalloproteinases1,2,and7(MMP1/2/7)andpreventingactivationofERK,p38MAPK,andAP-1.Additionally,ginsenosideRdinhibitsthe26Sproteasomeandtransientreceptorpotentialmelastatin-like7(TRPM7)channels,inhibitingproliferationofbreastcancerandgastriccancercells.

ProductInfo

CasNo.	52705-93-8
Purity	≥98%
Formula	C₄₈H₈₂O₁₈
FormulaWt.	947.16
Synonym	GypenosideVIII
Appearance	AlmostWhiteCrystalPowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	G3456MSDSPDF
InfoSheet	G3456InfoSheetPDF

References

ZhuD,LiuM,YangY,etal.GinsenosideRdamelioratesexperimentalautoimmuneencephalomyelitisinC57BL/6mice.JNeurosciRes.2014Sep;92(9):1217-26.PMID:24798871.

ZhangYX,WangL,XiaoEL,etal.Ginsenoside-Rdexhibitsanti-inflammatoryactivitiesthroughelevationofantioxidantenzymeactivitiesandinhibitionofJNKandERKactivationinvivo.IntImmunopharmacol.2013Dec;17(4):1094-100.PMID:24455777.

WangY,LiX,WangX,etal.GinsenosideRdattenuatesmyocardialischemia/reperfusioninjuryviaAkt/GSK-3βsignalingandinhibitionofthemitochondria-dependentapoptoticpathway.PLoSOne.2013Aug16;8(8):e70956.PMID:23976968.

LiL,LiuZ,LiuJ,etal.GinsenosideRdattenuatesbeta-amyloid-inducedtauphosphorylationbyalteringthefunctionalbalanceofglycogensynthasekinase3betaandproteinphosphatase2A.NeurobiolDis.2013Jun;54:320-8.PMID:23321003.

KimBJ.Involvementofmelastatintypetransientreceptorpotential7channelsinginsenosideRd-inducedapoptosisingastricandbreastcancercells.JGinsengRes.2013Apr;37(2):201-9.PMID:23717173.

YoonJH,ChoiYJ,ChaSW,etal.Anti-metastaticeffectsofginsenosideRdviainactivationofMAPKsignalingandinductionoffocaladhesionformation.Phytomedicine.2012Feb15;19(3-4):284-92.PMID:21982435.

ChangTL,DingHY,KaoYW.RoleofginsenosideRdininhibiting26Sproteasomeactivity.JAgricFoodChem.2008Dec24;56(24):12011-5.PMID:19053398.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂