Description
Glabridin is a phytoestrogen and isoflavonoid originally found in the root of the licorice plant, Glycyrrhiza. Glabridin displays antioxidative, anti-obesity, anti-angiogenic, neuromodulatory, cognition enhancing, and sedative/hypnotic characteristics. In osteoblasts, glabridin downregulates PI3K and Akt and upregulates superoxide dismutase 1 and glutathione peroxidase 4; it also promotes fatty acid oxidation and inhibits adipogenesis. In animal models, this compound improves learning and memory, potentially through positive modulation of the GABA-A receptor. Additionally, glabridin inhibits Rho signaling by decreasing FAK and Src activation, inhibiting cancer cell migration and invasion as well as angiogenesis in vitro and in vivo.
References
Jin Z, Kim S, Cho S, et al. Potentiating Effect of Glabridin on GABAA Receptor-Mediated Responses in Dorsal Raphe Neurons. Planta Med. 2013 Aug 23. [Epub ahead of print]. PMID: 23975867.
Kim HS, Suh KS, Ko A, et al. The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells. Int J Mol Med. 2013 Jan;31(1):243-51. PMID: 23128413.
Ahn J, Lee H, Jang J, et al. Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice. Food Chem Toxicol. 2013 Jan;51:439-45. PMID: 22967722.
Lee JW, Choe SS, Jang H, et al. AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. J Lipid Res. 2012 Jul;53(7):1277-86. PMID: 22493094.
Hasanein P. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta Physiol Hung. 2011 Jun;98(2):221-30. PMID: 21616781.
Tsai YM, Yang CJ, Hsu YL, et al. Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway. Integr Cancer Ther. 2011 Dec;10(4):341-9. PMID: 21059620.
