Gliclazideisasulfonylureacompoundthatinhibitssulfonylurea1(SUR1)receptors,exhibitinganti-diabeticandantioxidativeactivities.InhibitionofthesereceptorsclosesK+ionchannels,inducingcellmembranedepolarization,alteringCa2+homeostasis,andstimulatinginsulinrelease.Invitro,gliclazideinhibitsH2O2-inducedmitochondrialdamageandapoptosis,decreasingoxidativestress.
| CasNo. | 21187-98-4 |
|---|---|
| Purity | ≥98% |
| Formula | C15H21N3O3S |
| FormulaWt. | 323.41 |
| ChemicalName | N-[[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]-carbonyl]-4-methylbenzenesulfonamide |
| IUPACName | 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea |
| Synonym | Diamicron;Glimicron;Nordialex |
| MeltingPoint | 180-182°C |
| Solubility | Insolubleinwater.Solubleindichloromethane. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | G4532MSDSPDF |
|---|---|
| InfoSheet | G4532InfoSheetPDF |
ProksP,deWetH,AshcroftFM.MolecularmechanismofsulphonylureablockofK(ATP)channelscarryingmutationsthatimpairATPinhibitionandcauseneonataldiabetes.Diabetes.2013Nov;62(11):3909-19.PMID:23835339.
SliwinskaA,RogalskaA,SzwedM,etal.Gliclazidemayhaveanantiapoptoticeffectrelatedtoitsantioxidantpropertiesinhumannormalandcancercells.MolBiolRep.2012May;39(5):5253-67.PMID:22183301.
LawrenceCL,ProksP,RodrigoGC,etal.Gliclazideproduceshigh-affinityblockofKATPchannelsinmouseisolatedpancreaticbetacellsbutnotratheartorarterialsmoothmusclecells.Diabetologia.2001Aug;44(8):1019-25.PMID:11484080.
