Glucagon-likepeptide1(GLP-1)isanendogenouspeptidehormonethatbindsGLP-1receptors,increasingcAMPandinsulinsecretion.GLP-1primarilyexhibitsanorexigenic,anti-diabetic,andgastrointestinalmodulatoryactivities.GLP-1decreasesfoodintakeandglucagonlevelsinanimalmodelsandalsoslowsgastricemptying.Insubjectswithtype2diabetes,theresponseofGLP-1toglucoseisimpairedandsubjectsshowabnormallylowlevelsofGLPs.
| CasNo. | 106612-94-6 |
|---|---|
| Purity | ≥95% |
| Formula | C151H228N40O47 |
| FormulaWt. | 3355.67 |
| Synonym | Insulinotropin,Tglp-1;GLP-1 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | G4482InfoSheetPDF |
|---|
KimS,WanKimS,BaeYH.Synthesis,bioactivityandspecificityofglucagon-likepeptide-1(7-37)/polymerconjugatetoisolatedratislets.Biomaterials.2005Jun;26(17):3597-606.PMID:15621250.
VahlTP,PatyBW,FullerBD,etal.EffectsofGLP-1-(7-36)NH2,GLP-1-(7-37),andGLP-1-(9-36)NH2onintravenousglucosetoleranceandglucose-inducedinsulinsecretioninhealthyhumans.JClinEndocrinolMetab.2003Apr;88(4):1772-9.PMID:12679472.
MannucciE,OgnibeneA,CremascoF,etal.Glucagon-likepeptide(GLP)-1andleptinconcentrationsinobesepatientswithType2diabetesmellitus.DiabetMed.2000Oct;17(10):713-9.PMID:11110504.
NauckMA.Glucagon-likepeptide1(GLP-1):apotentguthormonewithapossIBLetherapeuticperspective.ActaDiabetol.1998Oct;35(3):117-29.PMID:9840447.
