Description
Glucosamineisanendogenousaminosugarprecursortoglycosylatedproteinandlipidformation;itisusedinthemakingofcartilage.Glucosamineimprovesjointfunctionandisoftenfoundindietarysupplements.Glucosamineexhibitsanticancerandanti-fibroticactivities.Inprostatecancercells,glucosaminedecreasesN-glycosylationofgp130,suppressingbindingofIL-6,phosphorylationofJAK2,SHP2,andSTAT3,andcellularproliferation.Additionally,glucosaminedecreasesTGF-β1-inducedexpressionofcollagenI,fibronectin,andα-SMA,inhibitsphosphorylationofSmad2/3,andsuppressesthedevelopmentofrenalfibrosisinvivo.