Growthhormonereleasinghexapeptide(GHRP-6)isasyntheticmet-enkephalinanalogthatinducesthereleaseofgrowthhormoneinvivothroughbindingoftheghrelinreceptor.GHRP-6increasesproliferationinastrocytesthroughamechanismthatinvolvesPI3K/Aktsignaling.GHRP-6alsoinhibitsdevelopmentofrestraintstress-inducedgastriclesionsandreversesovariectomy-inducedeffectsonserumglucoseandinsulinlevels.Additionally,GHRP-6decreaseslocomotoractivityandincreasesfoodintakeinvivo.
| CasNo. | 87616-84-0 |
|---|---|
| Purity | ≥95% |
| Formula | C46H56N12O6 |
| FormulaWt. | 873.04 |
| IUPACName | (2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide |
| Synonym | Growthhormonereleasinghexapeptide,Skf110679;GHRP-6 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | G2969MSDSPDF |
|---|---|
| InfoSheet | G2969InfoSheetPDF |
BaquedanoE,ChowenJA,ArgenteJ,etal.DifferentialeffectsofGHandGH-releasingpeptide-6onastrocytes.JEndocrinol.2013Jul29;218(3):263-74.PMID:23792323.
GuoS,GaoQ,JiaoQ,etal.Gastricmucosaldamageinwaterimmersionstress:mechanismandpreventionwithGHRP-6.WorldJGastroenterol.2012Jun28;18(24):3145-55.PMID:22791951.
ElbassuoniE,RagyM,AzizN.ProtectiveeffectofGHRP-6andestrogensupplementationagainstsomecardiometabolicriskfactorsinovariectomizedrats.EndocrRegul.2012Apr;46(2):73-81.PMID:22540855.
YahashiS,KangKS,KaiyaH,etal.GHRP-6mimicsghrelin-inducedstimulationoffoodintakeandsuppressionoflocomotoractivityingoldfish.Peptides.2012Apr;34(2):324-8.PMID:22349352.
