RimonabantisaninverseagoNISTatCB1receptorsthatwasbrieflyexploredasananti-obesitytreatmentbuthassincebeenwithdrawnduetoconcernsaboutinducingdepressivestatesinsubjects.Inanimalmodels,rimonabantdecreasesfoodintake.Rimonabantalsoinhibitsbindingofantagoniststoδ-opioidreceptorsinvitro.Inretinalpigmentepithelialcells,rimonabantpreventsoxidativeinjuryinaPI3K/Akt-dependentmanner.
| CasNo. | 158681-13-1 |
|---|---|
| Purity | ≥98% |
| FormulaWt. | 500.25 |
| IUPACName | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide;hydrochloride |
| Synonym | SR141716 |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R3449InfoSheetPDF |
|---|
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ZádorF,KocsisD,BorsodiA,etal.Micromolarconcentrationsofrimonabantdirectlyinhibitsdeltaopioidreceptorspecificligandbindingandagonist-inducedG-proteinactivity.NeuRochemInt.2014Feb;67:14-22.PMID:24508403.
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