S-acetyl-L-glutathioneisaglutathionederivativethatcanincreaseintracellularglutathionesimilartoaprodrug.ItcanbeusedtoreplenishthedepletionofreducedglutathioneoccurringduringHIVinfectionandtoinhibitHIVreplication.However,itwasfoundtoselectivelyinduceapoptosisinhumanlymphomacells,Daudi,RajiandJurkatcells,bydepletingtheintracellularglutathionelevelratherthanincreaseit.
| CasNo. | 3054-47-5 |
|---|---|
| Purity | ≥98% |
| Formula | C12H19N3O7S |
| FormulaWt. | 349.36 |
| ChemicalName | 5-[[3-acetylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-amino-5-oxopentanoicacid |
| IUPACName | γ-Glutamyl-S-acetylcysteinylglycine |
| Synonym | L-glutathione,S-acetyl |
| MeltingPoint | 199-204°C(dec.) |
| Solubility | Solubleinhotwater.Practicallyinsolubleincoldwater. |
| Appearance | WhitePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A1016InfoSheetPDF |
|---|
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LocignoR1,PincemailJ,HennoA,et.al.S-acetyl-glutathioneselectivelyinducesapoptosisinhumanlymphomacellsthroughaGSH-independentmechanism.IntJOncol.2002Jan;20(1):69-75.PMID:11743644
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