S-acetyl-L-glutathione is a glutathione derivative that can increase intracellular glutathione similar to a prodrug. It can be used to replenish the depletion of reduced glutathione occurring during HIV infection and to inhibit HIV replication. However, it was found to selectively induce apoptosis in human lymphoma cells, Daudi, Raji and Jurkat cells, by depleting the intracellular glutathione level rather than increase it.
| Cas No. | 3054-47-5 |
|---|---|
| Purity | ≥98% |
| Formula | C12H19N3O7S |
| Formula Wt. | 349.36 |
| Chemical Name | 5-[[3-acetylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-amino-5-oxopentanoic acid |
| IUPAC Name | γ-Glutamyl-S-acetylcysteinylglycine |
| Synonym | L-glutathione, S-acetyl |
| Melting Point | 199-204°C (dec.) |
| Solubility | Soluble in hot water. Practically insoluble in cold water. |
| Appearance | White Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | A1016 Info Sheet PDF |
|---|
Fraternale A1, Paoletti MF, Casabianca A, et.al. Inhibition of murine AIDS by pro-glutathione (GSH) molecules. Antiviral Res. 2008 Feb;77(2):120-7. PMID: 18164447
Locigno R1, Pincemail J, Henno A, et.al. S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Int J Oncol. 2002 Jan;20(1):69-75. PMID: 11743644
Galzigna L1, Rizzoli V, Schiappelli P et.al. S-acetyl- and S-phenylacetyl-glutathione as glutathione precursors in rat plasma and tissue preparations. Enzyme Protein. 1994-1995;48(2):98-104. PMID: 7581748
