Secretinisanendogenouspeptidehormoneinvolvedindigestionandfeedingbehavior;itbindstoitsownGPCRsecretinreceptor(SCTR).InADIpocytes,secretinstimulateslipolysis,mediatedbyPKAandhormone-sensitivelipase(HSL)signaling;italsoinducesuptakeoffattyacidsandsecretionofMCP-1andadiponectin.Secretinenhancesambulationdistancebutnotexploratoryactivityinanimalmodelsofrepetitivehyperactivity.Additionally,secretinincreasesexpressionoftyrosinehydroxylase,stimulatingcatecholaminesecretioninPC12neurons.
| CasNo. | 17034-35-4 |
|---|---|
| Purity | ≥95% |
| Formula | C130H220N44O41 |
| FormulaWt. | 3055.4 |
| Synonym | SecreFlo |
| Solubility | Solubleinwaterorsaline. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S1606InfoSheetPDF |
|---|
SekarR,ChowBK.Lipolyticactionsofsecretininmouseadipocytes.JLipidRes.2014Feb;55(2):190-200.PMID:24273196.
MiegueuP,CianfloneK,RichardD,etal.Effectofsecretinonpreadipocyte,differentiatingandmatureadipocytefunctions.IntJObes(Lond).2013Mar;37(3):366-74.PMID:22565418.
HeinzlmannA,KissG,TóthZE,etal.Intranasalapplicationofsecretin,similarlytointracerebroventricularadmiNISTration,influencesthemotorbehaviorofmiceprobablythroughspecificreceptors.JMolNeurosci.2012Nov;48(3):558-64.PMID:22752505.
MahataM,ZhangK,GayenJR,etal.Catecholaminebiosynthesisandsecretion:physiologicalandpharmacologicaleffectsofsecretin.CellTissueRes.2011Jul;345(1):87-102.PMID:21597914.
