LKT/SILYBIN/S3343/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/SILYBIN/S3343/1 g

LKT/SILYBIN/S3343/1 g

商品编号： S3343-1g

品牌： lktlabs

市场价： ¥740.00

美元价： 444.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDS3343

CasNo.22888-70-6

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Silybinisaphytoestrogenandflavonoidoriginallyfoundintheseedsofthemilkthistleplant(Silybum).Silybinexhibitsanti-diabetic,anti-inflammatory,anti-angiogenic,anticancerchemotherapeutic,andchemopreventiveactivities.Incellularandanimalmodelsofhepatocellularcarcinoma,silybinincreasesexpressionofTRAILandDR-5,activatescaspasesignaling,anddecreasestumorgrowthandinflammatorycytokinerelease.Inanimalmodelsofdiabetes,silybindecreaseHb1Aclevelsaswellasserumtriglycerides,cholesterol,andglucoseinpancreaticβcells.Additionally,silybininhibitsIL-1β-inducedpro-inflammatorycytokineexpressionandsuppressestranslocationofNF-κBinvitro.Inanimalmodels,thiscompoundsuppressesexpressionofHIF-1αandVEGF,decreasesmicrovesseldensity,anddelaysUV-inducedcarcinogenesis.

ProductInfo

CasNo.	22888-70-6
Purity	≥97%
Formula	C₂₅H₂₂O₁₀
FormulaWt.	482.44
ChemicalName	(2R,3R)-2-[(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-oneAND(2R,3R)-2-[(2S,3S)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
IUPACName	(2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
Synonym	Silibinin;SilybumsubstanceE6;SilymarinI
MeltingPoint	167°C°r180°C(dec.)
Solubility	Solubleinacetone,ethylacetate,methanolorethanol.Practicallyinsolubleinwater.
Appearance	Whitetolightyellowpowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	S3343MSDSPDF
InfoSheet	S3343InfoSheetPDF

References

BousSEROuelS,BourG,KauntzH,etal.SilibinininhibitstumorgrowthinamurineorthotopichepatocarcinomamodelandactivatestheTRAILapoptoticsignalingpathway.AnticancerRes.2012Jul;32(7):2455-62.PMID:22753701.

WangQ,LiuM,LiuWW,etal.Invivorecoveryeffectofsilibinintreatmentonstreptozotocin-induceddiabeticmiceisassociatedwiththemodulationsofSirt-1expressionandautophagyinpancreaticβ-cell.JAsianNatProdRes.2012;14(5):413-23.PMID:22423887.

AuAY,HasenwinkelJM,FrondozaCG.Silybininhibitsinterleukin-1β-inducedproductionofpro-inflammatorymediatorsincaninehepatocytecultures.JVetPharmacolTher.2011Apr;34(2):120-9.PMID:21395602.

GuM,SinghRP,DhanalakshmiS,etal.SilibinininhibitsinflammatoryandangiogenicattributesinphotocarcinogenesisinSKH-1hairlessmice.CancerRes.2007Apr1;67(7):3483-91.PMID:17409458.

LeeMH,HuangZ,KimDJ,etal.DirecttargetingofMEK1/2andRSK2bysilybininducescell-cyclearrestandinhibitsmelanomacellgrowth.CancerPrevRes(Phila).2013May;6(5):455-465.PMID:23447564.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂