LKT/SILYMARIN/S3345/10 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/SILYMARIN/S3345/10 g

LKT/SILYMARIN/S3345/10 g

商品编号： S3345-10g

品牌： lktlabs

市场价： ¥880.00

美元价： 528.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDS3345

CasNo.65666-07-1

Purity≥70%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

SilymarinisaflavonolignanmixturefoundinSilybum(milkthistle)seeds;itexhibitsantiviral,anti-inflammatory,anti-fibrotic,hepatoprotective,neuroprotective,immunosuppressive,antioxidative,andanticanceractivities.SilymarininhibitsinfluenzavirusproliferationbysuppressingviralRNAsynthesis.Inanimalmodelsofbenignprostatichyperplasia(BPH),silymarindecreasesinflammation,collagendeposition,andlevelsofiNOS,COX-2,NF-κB,IL-6,IL-8,andHIF-1α.Inanimalmodelsoffibrosis,silymarindecreasesoxidativestress,fibrosisdevelopment,andlevelsofα-SMAandTGF-β1.SilymarinshowspotentialbenefitinmodelsofParkinson’sdiseaseandAlzheimer’sdisease,inhibitingaggregationofproteinssuchasamyloid-β(Aβ).InactivatedTcells,silymarininducesG1phasecellcyclearrestanddecreasesmTORsignaling.ThiscompounddecreaseslipidperoxidationandincreasesrADIcalscavengingandlevelsofglutathioneinvivo.Inovariancancercells,silymarinincreasesexpressionofPTEN,decreasessignalingbyAktandexpressionofBcl-2,inducesapoptosis,andinhibitscellularproliferation;italsoinhibitstelomeraseactivity.

ProductInfo

CasNo.	65666-07-1
Purity	≥70%
Formula	C₂₅H₂₂O₁₀
FormulaWt.	482.44
IUPACName	(2S)-3,5,7-trihydroxy-2-[(2S,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
Synonym	Apihepar;Laragon;Legalon;Pluropon;Silarine;Silliver
Solubility	SolubleinDMSOorethanol.
Appearance	YellowishPowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	S3345InfoSheetPDF

References

AtawiaRT,MosliHH,TadrosMG,etal.Modulatoryeffectofsilymarinoninflammatorymediatorsinexperimentallyinducedbenignprostatichyperplasia:emphasisonPTEN,HIF-1α,andNF-κB.NaunynSchmiedebergsArchPharmacol.2014Aug28.[Epubaheadofprint].PMID:25164963

ClichiciS,OlteanuD,NagyAL,etal.SilymarinInhibitstheProgressionofFibrosisintheEarlyStagesofLiverInjuryinCCl4-TreatedRats.JMedFood.2014Aug18.[Epubaheadofprint].PMID:25133972.

BorahA,PaulR,ChoudhuryS,etal.NeuroprotectivepotentialofsilymarinagainstCNSdisorders:insightintothepathwaysandmolecularmechanismsofaction.CNSNeurosciTher.2013Nov;19(11):847-53.PMID:24118806.

SuCH,ChenLJ,LiaoJF,etal.Increaseofphosphataseandtensinhomologbysilymarintoinhibithumanpharynxsquamouscancer.JMedFood.2013Sep;16(9):778-84.PMID:23909904.

KwondoY,JungYS,KimSJ,etal.Alterationsinsulfuraminoacidmetabolisminmicetreatedwithsilymarin:anovelmechanismofitsactioninvolvedinenhancementoftheantioxidantdefenseinliver.PlantaMed.2013Aug;79(12):997-1002.PMID:23807810.

GharagozlooM,JavidEN,RezaeiA,etal.SilymarininhibitscellcycleprogressionandmTORactivityinactivatedhumanTcells:therapeuticimplicationsforautoimmunediseases.BasicClinPharmacolToxicol.2013Apr;112(4):251-6.PMID:23121838.

FaezizadehZ,Mesbah-NaminSA,AllamehA.TheeffectofsilymarinontelomeraseactivityinthehumanleukemiacelllineK562.PlantaMed.2012Jun;78(9):899-902.PMID:22532022.

SongJH,ChoiHJ.SilymarinefficacyagainstinfluenzaAvirusreplication.Phytomedicine.2011Jul15;18(10):832-5.PMID:21377857.

MurataN,MurakamiK,OzawaY,etal.SilymarinattenuatedtheamyloidbetaplaqueburdenandimprovedbehavorialabnormalitiesinanAlzheimer’sdiseasemousemodel.BiosciBiotechnolBiochem.2010;74(11):2299-2306.PMID:21071836.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂