Description
NeuromedinUisanendogenousneurohormoneinvolvedinmaintenanceofenergyhomeostasis.NeuromedinUexhibitsanorexigenic,Thermogenic,anxiolytic,hypertensive,andpro-inflammatoryactivities.Inseasonalanimals,neuromedinUincreasescoretemperatureanddecreasesfoodintakeandbodyweight;theseactivitiesaremediatedthroughactivationofWnt/β-cateninsignaling.NeuromedinUexhibitsanxiolyticbenefitinanimalsundergoingtheelevatedplusmazetest.NeuromedinUalsoinhibitsgastricacidsecretionandincreasesheartrateandbloodpressure.NeuromedinUbindsneuromedinreceptorsinovariancells,increasingproductionofprogesterone.Additionally,thishormoneupregulatesinflammation-relatedcytokinegeneexpressioninvitroinresponsetobacterialandviralpathogens.
References
HelferG,RossAW,MorganPJ.NeuromedinUpartlymimicsthyroidstimulatinghormoneandtriggersWnt/β-CateninsignallinginthephotoperiodicresponseofF344rats.JNeuroendocrinol.2013Oct24.[Epubaheadofprint].PMID:24164054.
TelegdyG,AdamikA.Anxiolyticactionofneuromedin-Uandneurotransmittersinvolvedinmice.RegulPept.2013Sep10;186:137-40.PMID:23892031.
LinTY,WuFJ,LeeWY,etal.OvarianregulationofneuromedinUanditslocalactionsintheovary,mediatedthroughneuromedinUreceptor2.AmJPhysiolEndocrinolMetab.2013Apr15;304(8):E800-9.PMID:23423171.
RahmanAA,ShahidIZ,PilowskyPM.DifferentialcardiorespiratoryandsympatheticreflexresponsestomicroinjectionofneuromedinUinratrostralventrolateralmedulla.JPharmacolExpTher.2012Apr;341(1):213-24.PMID:22262923.
KonoT,HamasunaS,KorenagaH,etal.TheroleofneuromedinUduringinflammatoryresponseinthecommoncarp.FishShellfishImmunol.2012Jan;32(1):151-60.PMID:22122861.