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商品详细LKT/神经降压素/N1989/1毫克
LKT/神经降压素/N1989/1毫克
LKT/神经降压素/N1989/1毫克
商品编号: N1989-1mg
品牌: lktlabs
市场价: ¥1680.00
美元价: 1008.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Neurotensin is an endogenous tridecapeptide that exhibits antinociceptive, pro-inflammatory, and gastrointestinal motility modulating activities; it binds and activates neurotensin (NTS) receptors. Neurotensin induces contractions in smooth muscle cells, playing a role in regulating digestive activity in vitro and in vivo. Additionally, neurotensin induces intracellular Ca2+ release, activating non-selective cation channels and altering pacemaker currents involved in gastrointestinal and colonic motility. In animal models, neurotensin displays sympatho-inhibitory activity, decreases blood pressure and heart rate. Neurotensin exerts its actions through activation of neurotensin receptors; activation of these receptors also stimulates orexin neurons, suggesting a role for neurotensin in mediation of reward, feeding, and wakefulness.

Product Info

Cas No.

39379-15-2

Purity

≥95%

Formula

C78H122N21O20

Formula Wt.

1672.9

IUPAC Name

2-[[2-[[2-[[1-[2-[[2-[[1-[6-amino-2-[[4-amino-2-[[4-carboxy-2-[[3-(4-hydroxyphenyl)-2-[[4-methyl-2-[(5-oxopyrrolidine-2-carbonyl)amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid

Solubility

Soluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N1989 MSDS PDF

Info Sheet

N1989 Info Sheet PDF

References

Kleczkowska P, Lipkowski AW. Neurotensin and neurotensin receptors: characteristic, structure-activity relationship and pain modulation--a review. Eur J Pharmacol. 2013 Sep 15;716(1-3):54-60. PMID: 23500196.

Degolier TF, Brown DR, Duke GE, et al. Neurotensin and cholecystokinin contract gallbladder circular muscle in chickens. Poult Sci. 2013 Aug;92(8):2156-62. PMID: 23873564.

Furutani N, Hondo M, Kageyama H, et al. Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. PLoS One. 2013 Apr 19;8(4):e62391. PMID: 23620827.

Lee J, Kim YD, Park CG, et al. Neurotensin modulates pacemaker activity in interstitial cells of Cajal from the mouse small intestine. Mol Cells. 2012 May;33(5):509-16. PMID: 22441675.

Zogovic B, Pilowsky PM. Intrathecal neurotensin is hypotensive, sympathoinhibitory and enhances the baroreflex in anaesthetized rat. Br J Pharmacol. 2012 May;166(1):378-89. PMID: 22035146.

Law IK, Murphy JE, Bakirtzi K, et al. Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1. J Biol Chem. 2012 Apr 27;287(18):15066-75. PMID: 22416137.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂