Omeprazoleisaprotonpumpinhibitor(PPI)thatactsasanantagoNISTatH+/K+ATPasesandisclinicallyusedtotreatgastroesophagealrefluxdisease(GERD),dyspepsia,andpepticulcerdisease.Omeprazoleexhibitsantacid,anti-ulcerative,andanti-diabeticactivities;italsoinhibitsthemitochondrialcarnitine/acylcarnitinetransporter.OmeprazoledecreasesbloodglucoselevelsandHb1Ac,improvesglucosetolerance,andinducesβcellneogenesisandactivation.
| CasNo. | 73590-58-6 |
|---|---|
| Purity | ≥98% |
| Formula | C17H19N3O3S |
| FormulaWt. | 345.42 |
| ChemicalName | 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole |
| IUPACName | 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole |
| Synonym | Antra;Gastrogard;Losec;Mepral;Omepral;Parizac"Prilosec;Zoltum |
| MeltingPoint | 156°C |
| Solubility | Solubleinethanolormethanol.Slightlysolubleinacetone,isopropanol,orwater. |
| Appearance | WhiteCrystallinepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | O4917MSDSPDF |
|---|---|
| InfoSheet | O4917InfoSheetPDF |
TonazziA,EberiniI,IndiveriC.Molecularmechanismofinhibitionofthemitochondrialcarnitine/acylcarnitinetransporterbyomeprazolerevealedbyproteoliposomeassay,mutagenesisandbioinformatics.PLoSOne.2013Dec9;8(12):e82286.PMID:24349247.
WardRM,KearnsGL.Protonpumpinhibitorsinpediatrics:mechanismofaction,pharmacokinetics,pharmacogenetics,andpharmacodynamics.PaediatrDrugs.2013Apr;15(2):119-31.PMID:23512128.
MeffordIN,MeffordJT,BurrisCA.Improveddiabetescontrolandpancreaticfunctioninatype2diabeticafteromeprazoleadministration.CaseRepEndocrinol.2012;2012:468609.PMID:22937295.
