Description
Orexin B is an endogenous peptide neurotransmitter that activates orexin-2 receptors (OX2), controlling pituitary functions and increasing secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Orexin B is also involved in sleep, arousal, and feeding behaviors. This compound exhibits neuroprotective and orexigenic activities. Orexin B increases phosphorylation of Akt, increasing neuronal viability and protecting neurons against oxidative stress. Orexin B also decreases latency to eating, increases feeding behavior, decreases anxiety, and increases arousal in vivo. Orexin B stimulates insulin secretion in the pancreas of rats in a β-adrenergic receptor-dependent manner.
References
Cataldi NI, Lux Lantos VA, Libertun C. Orexin A and B in vitro modify orexins receptors expression and gonadotropins secretion of anterior pituitary cells of proestrous rats. Regul Pept. 2014 Jan 10;188:25-30. PMID: 24333629.
Sokołowska P, Urbańska A, Biegańska K, et al. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J Mol Neurosci. 2014 Jan;52(1):48-55. PMID: 24243084.
Tsuji T, Yamamoto T, Tanaka S, et al. Analyses of the facilitatory effect of orexin on eating and masticatory muscle activity in rats. J Neurophysiol. 2011 Dec;106(6):3129-35. PMID: 21940607.
Adeghate E, Hameed R. Mechanism of orexin B-stimulated insulin and glucagon release from the pancreas of normal and diabetic rats. Pancreas. 2011 Jan;40(1):131-6. PMID: 20871474.
Di Sebastiano AR, Yong-Yow S, Wagner L, et al. Orexin mediates initiation of sexual behavior in sexually naive male rats, but is not critical for sexual performance. Horm Behav. 2010 Aug;58(3):397-404. PMID: 20541554.
