Description
PalmatineisanisoquinolinealkaloidfoundinCorydalis,Phellodendron,Enantia,andotherplants.Palmatineexhibitssedative,antidepressant,antioxidative,anti-ulcerative,antacid,anticancer,andanti-metastaticactivities.PalmatinebindshemoglobinandDNAatATbasepairs.Inanimalmodels,palmatinedecreaseslocomotoractivityandlevelsofdopamine,5-HT,andhomovanillicacid.Inprostatecancercells,palmatinedecreasesgrowthandinvasionaswellasactivationofFLIPandNF-κB.PalmatinealsodecreasesimmobilitytimeinanimalsundergoingtheforcedswimtestandtailsUSPensiontest.Inseparateanimalmodels,thiscompoundactsasarADIcalscavenger,inhibitsHelicobactergrowth,anddecreasesgastriculcerformation.
References
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