Description
Palmatine is an isoquinoline alkaloid found in Corydalis, Phellodendron, Enantia, and other plants. Palmatine exhibits sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities. Palmatine binds hemoglobin and DNA at AT base pairs. In animal models, palmatine decreases locomotor activity and levels of dopamine, 5-HT, and homovanillic acid. In prostate cancer cells, palmatine decreases growth and invasion as well as activation of FLIP and NF-κB. Palmatine also decreases immobility time in animals undergoing the forced swim test and tail suspension test. In separate animal models, this compound acts as a radical scavenger, inhibits Helicobacter growth, and decreases gastric ulcer formation.
References
Hambright HG, Batth IS, Xie J, et al. Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP. Mol Carcinog. 2014 Jul 7. [Epub ahead of print]. PMID: 25043857.
Liu B, Yan X, Cao S, et al. Studies on the interaction of palmatine hydrochloride with bovine hemoglobin. Luminescence. 2014 May;29(3):211-8. PMID: 23696111.
Jung J, Choi JS, Jeong CS. Inhibitory Activities of Palmatine from Coptis chinensis Against Helicobactor pylori and Gastric Damage. Toxicol Res. 2014 Mar;30(1):45-8. PMID: 24795799.
Dhingra D, Bhankher A. Behavioral and biochemical evidences for antidepressant-like activity of palmatine in mice subjected to chronic unpredictable mild stress. Pharmacol Rep. 2014 Feb;66(1):1-9. PMID: 24905299.
Bhadra K, Maiti M, Kumar GS. Molecular recognition of DNA by small molecules: AT base pair specific intercalative binding of cytotoxic plant alkaloid palmatine. Biochim Biophys Acta. 2007 Jul;1770(7):1071-80. PMID: 17434677.
Hsieh MT, Su SH, Tsai HY, et al. Effects of palmatine on motor activity and the concentration of central monoamines and its metabolites in rats. Jpn J Pharmacol. 1993 Jan;61(1):1-5. PMID: 7679763.
