PancreaticpolypeptideisanendogenousneuropeptideY-familyhormonethatexhibitsanorexigenicactivity.PancreaticpolypeptidebindstheY4receptortodecreasefoodintake,increaselocomotoractivity,andstimulatecolonicmusclecontractionsandtransit.Decreasedsecretionofpancreaticpolypeptideisassociatedwithimprovementsinpancreaticβ-cellfunctioninsubjectswithtype2diabetes.
| CasNo. | 58591-52-9 |
|---|---|
| Purity | ≥95% |
| Formula | C190H283N53O58 |
| FormulaWt. | 4237.69 |
| Synonym | Pancreatichormone,avian;PPY |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P0350InfoSheetPDF |
|---|
KahleovaH,MariA,NofrateV,etal.Improvementinβ-cellfunctionafterdiet-inducedweightlossisassociatedwithdecreaseinpancreaticpolypeptideinsubjectswithtype2diabetes.JDiabetesComplications.2012Sep-Oct;26(5):442-9.PMID:22673566.
HankirMK,ParkinsonJR,MinnionJS,etal.PeptideYY3-36andpancreaticpolypeptidedifferentiallyregulatehypothalamicneuronalactivityinmiceinvivoasmeasuredbymanganese-enhancedmagneticresonanceimaging.JNeuroendocrinol.2011Apr;23(4):371-80.PMID:21251093.
MoriyaR,FujikawaT,ItoJ,etal.PancreaticpolypeptideenhancescolonicmusclecontractionandfecaloutputthroughneuropeptideYY4receptorinmice.EurJPharmacol.2010Feb10;627(1-3):258-64.PMID:19818748.
LiuYL,SemjonousNM,MurphyKG,etal.Theeffectsofpancreaticpolypeptideonlocomotoractivityandfoodintakeinmice.IntJObes(Lond).2008Nov;32(11):1712-5.PMID:18779824.
