PantoprazoleisanH+/K+ATPaseinhibitorthatexhibitsantacid,anti-parasitic,andanticancerchemotherapeuticactivities.Pantoprazoleisclinicallyusedtotreatgastroesophagealrefluxdisease(GERD),althoughitsinhibitionofROCK-2causesadecreaseingastroesophagealsphinctermuscletone.InTrichomonas,pantoprazoleinhibitsuridinenucleosideribohydrolaseactivity.Additionally,pantoprazoleincreasestumor-associatedmacrophagerecruitmentinthetumormicroenvironment,inhibitingtumorgrowthinvivo.
| CasNo. | 164579-32-2 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14F2N3NaO4S•3/2H2O |
| FormulaWt. | 432.37 |
| ChemicalName | 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazolesodiumsalt |
| IUPACName | sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide |
| Synonym | Eupantol;Pantozol;Protonix;Somac |
| MeltingPoint | >30°C(dec) |
| Solubility | Solubleinwaterorethanol. |
| Appearance | Almostwhiteorwhitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P0256InfoSheetPDF |
|---|
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SheaTA,BurburanPJ,MatubiaVN,etal.Identificationofproton-pumpinhibitordrugsthatinhibitTrichomonasvaginalisuridinenucleosideribohydrolase.BioorgMedChemLett.2014Feb15;24(4):1080-4.PMID:24468412.
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