Peptidehistidineisoleucine(PHI)isanendogenousbrain-gutpeptidethatactivatesVPAC2receptors.PHIexhibitsanorexigenicactivityinvivo,decreasingfeedingbehaviorinanoxytocin-mediatedmanner.PHIalsodecreasescaspase3activityandincreasesglutamatetransporter(GLT-1a)activityinvitro.ThispeptideinhibitsproliferationofneuroblastomacellsinaMAPK-mediatedmannerandappearstoplayaroleincircADIanrhythmmanagement.
| CasNo. | 80458-29-3 |
|---|---|
| Purity | ≥97% |
| Formula | C136H216N36O40 |
| FormulaWt. | 2995.39 |
| Synonym | PHI |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P2832InfoSheetPDF |
|---|
GoursaudS,FocantMC,BergerJV,etal.TheVPAC2agoNISTpeptidehistidineisoleucine(PHI)up-regulatesglutamatetransportinthecorpuscallosumofaratmodelofamyotrophiclateralsclerosis(hSOD1G93A)byinhibitingcaspase-3mediatedinactivationofGLT-1a.FASEBJ.2011Oct;25(10):3674-86.PMID:21730107.
ColwellCS,MichelS,ItriJ,etal.DisruptedcircadianrhythmsinVIP-andPHI-deficientmice.AmJPhysiolRegulIntegrCompPhysiol.2003Nov;285(5):R939-49.PMID:12855416.
OlszewskiPK,WirthMM,ShawTJ,etal.Peptidesthatregulatefoodintake:effectofpeptidehistidineisoleucineonconsummatorybehaviorinrats.AmJPhysiolRegulIntegrCompPhysiol.2003Jun;284(6):R1445-53.PMID:12595279.
LelièvreV,PineauN,DuJ,etal.Differentialeffectsofpeptidehistidineisoleucine(PHI)andrelatedpeptidesonstimulationandsuppressionofneuroblastomacellproliferation.AnovelVIP-independentactionofPHIviaMAPkinase.JBiolChem.1998Jul31;273(31):19685-90.PMID:9677397.
