Description
PeptideYYisanendogenousneuropeptideY-relatedpeptidethatactivatesY1andY2receptors.PeptideYYisanappetite-regulatinghormonesecretedfromthegastrointestinaltractthatexhibitsanorexigenicactivity.PeptideYYdecreasesosteoblastactivity,contributingtobonelossinclinicalsettingsinwhichpatientshaverecentlylostweight.PeptideYYalsodecreaseslevelsofAMPKandphosphorylatedacetylCoAcarboxylaseintheliver,decreasinglipidoxidationand/orincreasinglipogenesis.PeptideYYalsoinducesslightimprovementsininsulinresponseduringglucosechallengeinanimalmodels.Inotherinvivomodels,peptideYYinducesmucosalanti-secretoryactivity,inhibitingcolonicanduppergastrointestinaltransit.