LKT/PIOGLITAZONE HYDROCHLORIDE/P6954/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PIOGLITAZONE HYDROCHLORIDE/P6954/100 mg

LKT/PIOGLITAZONE HYDROCHLORIDE/P6954/100 mg

商品编号： P6954-100mg

品牌： lktlabs

市场价： ¥1040.00

美元价： 624.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDP6954

CasNo.112529-15-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PioglitazoneisathiazolidinedionethatactsasanagoNISTatPPARα/γreceptorsandalsobindsmitoNEET,amitochondrialproteininvolvedinenergyhomeostasis.Pioglitazoneexhibitsanti-diabetic,antacid,antidepressant,antinociceptive,andanti-diarrhealactivities.Invivo,pioglitazonedecreaseslevelsofHDL,triglycerides,totalcholesterol,insulin,bloodglucose,andHb1Ac.Pioglitazonemayalsohaveeffectsonangiogenesis,decreasingexpressionofHIF-1αandVEGFbutincreasingmicrovesseldensityinanimalmodelsofhindlimbischemia.ThiscompoundinhibitsformationofulcersinvivopotentiallyduetoinhibitionofIL-1βandiNOSandinductionofcNOS.Additionally,pioglitazonedecreasesvisceralhypersensitivity,suppressesdefecation,andincreasesnociceptivethresholdsinvivo.

ProductInfo

CasNo.	112529-15-4
Purity	≥98%
Formula	C₁₉H₂₀N₂O₃S•HCl
FormulaWt.	392.91
ChemicalName	2,4-Thiazolidinedione,5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-,monohydrochloride,(+-)-
IUPACName	5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride
Synonym	Actos;U-72107A.
MeltingPoint	193-194°C
Solubility	SolubleinDMF,DMSO(79mg/mL).Slightlysolubleinethanol(4mg/mL).acetoneoracetonitrile.Practicallyinsolubleinwater.Insolubleinether.
Appearance	Whitetooff-WhiteCrystallinePowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	P6954MSDSPDF
InfoSheet	P6954InfoSheetPDF

References

ZhangM,GaoX,BaiSJ,etal.Effectofpioglitazoneonexpressionofhypoxia-inducIBLefactor1αandvascularendothelialgrowthfactorinischemichindlimbofdiabeticrats.EurRevMedPharmacolSci.2014;18(9):1307-14.PMID:24867508.

KempDE,SchinagleM,GaoK,etal.PPAR-γagonismasamodulatorofmood:proof-of-conceptforpioglitazoneinbipolardepression.CNSDrugs.2014Jun;28(6):571-81.PMID:24715548.

ParagomiP,RahimianR,KazemiMH,etal.Antinociceptiveandantidiarrhealeffectsofpioglitazoneinaratmodelofdiarrhoea-predominantirritablebowelsyndrome:roleofnitricoxide.ClinExpPharmacolPhysiol.2014Feb;41(2):118-26.PMID:24471407.

MoeziL,HeidariR,AmirghofranZ,etal.Enhancedanti-ulcereffectofpioglitazoneongastriculcersincirrhoticrats:theroleofnitricoxideandIL-1β.PharmacolRep.2013;65(1):134-43.PMID:23563031.

PaddockML,WileySE,AxelrodHL,etal.MitoNEETisauniquelyfolded2Fe2SoutermitochondrialmembraneproteinstABIlizedbypioglitazone.ProcNatlAcadSciUSA.2007Sep4;104(36):14342-7.PMID:17766440.

GilliesPS,DunnCJ.Pioglitazone.Drugs.2000Aug;60(2):333-43;PMID:10983737.

YoshidaH,WatanabeW,OomagariH,etal.CitrusflavonoidnaringenininhibitsTLR2expressioninADIpocytes.JNutrBiochem.2013Jul;24(7):1276-1284.PMID:23333096.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂