Description
Prolactin-releasing peptide (PrP) is an endogenous peptide hormone that binds GPR10 receptors and stimulates leutinizing hormone-releasing hormone (LHRH) release, causing secretion of leutinizing hormone (LH) and follicle-stimulating hormone (FSH) in the hypothalamus. PrP also induces prolactin release in female animals. PrP secretion is increased by food intake and it forms a negative feedback loop by exhibiting anorexigenic activity, decreasing food intake in an oxytocin-dependent manner. PrP exhibits some immunostimulatory and potentially pro-inflammatory activities, increasing expression of pro-inflammatory cytokines and ROS in leukocytes.
References
Yamashita M, Takayanagi Y, Yoshida M, et al. Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake. J Neuroendocrinol. 2013 May;25(5):455-65. PMID: 23363338.
Romero A, Manríquez R, Alvarez C, et al. Prolactin-releasing peptide is a potent mediator of the innate immune response in leukocytes from Salmo salar. Vet Immunol Immunopathol. 2012 Jun 30;147(3-4):170-9. PMID: 22578983.
Seal LJ, Small CJ, Kim MS, et al. Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats. Endocrinology. 2000 May;141(5):1909-12. PMID: 10803604.
