Description
Resiniferatoxin is an analog of capsaicin found in Euphorbia; it activates transient receptor potential vanilloid (TRPV) channels and PKC. Resiniferatoxin exhibits neuromodulatory, analgesic, anti-ulcerative, antiemetic, and thermoregulatory activities. Resiniferatoxin increases glutamate release in neurons, facilitating nociceptive neurotransmission. In animal models of prostatodynia, resiniferatoxin desensitizes TRPV channels, decreasing pain. In other animal models, this compound inhibits the formation of gastric lesions. Additionally, resiniferatoxin decreases body temperature in vivo.
References
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