Description
ResiniferatoxinisananalogofcapsaicinfoundinEuphorbia;itactivatestransientreceptorpotentialvanilloid(TRPV)channelsandPKC.Resiniferatoxinexhibitsneuromodulatory,analgesic,anti-ulcerative,antiemetic,andThermoregulatoryactivities.Resiniferatoxinincreasesglutamatereleaseinneurons,facilitatingnociceptiveneurotransmission.Inanimalmodelsofprostatodynia,resiniferatoxindesensitizesTRPVchannels,decreasingpain.Inotheranimalmodels,thiscompoundinhibitstheformationofgastriclesions.Additionally,resiniferatoxindecreasesbodytemperatureinvivo.
References
JiangCY,FujitaT,YueHY,etal.Effectofresiniferatoxinonglutamatergicspontaneousexcitatorysynaptictransmissioninsubstantiagelatinosaneuronsoftheadultratspinalcord.Neuroscience.2009Dec29;164(4):1833-44.PMID:19778582.
TangW,SongB,ZhouZS,etal.IntrathecaladmiNISTrationofresiniferatoxinproducesanalgesiaagainstprostatodyniainrats.ChinMedJ(Engl).2007Sep20;120(18):1616-21.PMID:17908482.
HorieS,YamamotoH,MichaelGJ,etal.Protectiveroleofvanilloidreceptortype1inHCl-inducedgastricmucosallesionsinrats.ScandJGastroenterol.2004Apr;39(4):303-12.PMID:15125461.
GeigesD,MeyerT,MarteB,etal.ActivationofproteinkinaseCsubtypesalpha,gamma,delta,epsilon,zeta,andetabytumor-promotingandnontumor-promotingagents.BiochemPharmacol.1997Mar21;53(6):865-75.PMID:9113106.
WoodsAJ,StockMJ,GuptaAN,etal.Thermoregulatoryeffectsofresiniferatoxinintherat.EurJPharmacol.1994Oct24;264(2):125-33.PMID:7851474.
AndrewsPL,BhandariP.Resinferatoxin,anultrapotentcapsaicinanalogue,hasanti-emeticpropertiesintheferret.Neuropharmacology.1993Aug;32(8):799-806.PMID:8413843.
